Dietary fish intake and incident atrial fibrillation (from the Women's Health Initiative).
Dietary fish intake and incident atrial fibrillation (from the Women's Health Initiative).
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DOI：
10.1016/j.amjcard.2009.11.039
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发表时间：
2010-03-15
影响因子：
2.8
通讯作者：
Lloyd-Jones, Donald M.
中科院分区：
文献类型：
--
作者：
Berry, Jarett D.;Prineas, Ronald J.;van Horn, Linda;Passman, Rod;Larson, Joseph;Goldberger, Jeffrey;Snetselaar, Linda;Tinker, Lesley;Liu, Kiang;Lloyd-Jones, Donald M.
实验和临床试验数据表明鱼油摄入量与心房纤颤（AF）之间存在关联。然而，先前的观察性研究报告了关于这种关联的相互矛盾的结果。因此，我们试图在一个大样本的老年绝经后妇女中比较饮食中鱼类摄入量和AF事件之间的关联。我们纳入了44，720名来自妇女健康倡议临床试验的参与者，这些参与者没有参加饮食调整干预组，并且在基线时没有AF。非油炸鱼的饮食摄入量和ω-3脂肪酸摄入量在研究开始时通过食物频率问卷进行估计。在第3年和第6年通过随访ECG确定AF事件。在鱼类摄入量的四分位数（Q）之间比较基线特征和AF事件发生率。调整后的逻辑回归模型被用来评估饮食非油炸鱼摄入量和AF事件之间的关联。有378例AF事件的后续行动。在年龄调整模型中，饮食非油炸鱼类摄入量与AF事件之间没有关联[饮食鱼类摄入量Q4与Q1的比值比（95%置信区间）为1.17（0.88-1.57））。在多变量模型和亚组分析中观察到类似的结果。在一个大型健康女性队列中，我们没有发现鱼类或omega-3脂肪酸摄入与AF事件之间存在关联的证据。
Experimental and clinical trial data suggest an association between fish oil intake and atrial fibrillation (AF). However, prior observational studies have reported conflicting results regarding this association. Thus, we sought to compare the association between dietary fish intake and incident AF in a large sample of older, postmenopausal women. We included 44,720 participants from the Women's Health Initiative clinical trials not enrolled in the dietary modification intervention arm and without AF at baseline. The dietary intake of non-fried fish and omega-3 fatty acid intake were estimated from a Food Frequency Questionnaire at study entry. Incident AF was determined by follow-up ECG at year 3 and year 6. Baseline characteristics and rates of incident AF were compared across quartiles (Q) of fish intake. Adjusted logistic regression models were used to evaluate the association between dietary non-fried fish intake and incident AF. There were 378 incident cases of AF in follow-up. In age-adjusted models, there was no association between dietary non-fried fish intake and incident AF [odds ratios (95% confidence intervals) 1.17 (0.88–1.57) for Q 4 vs. Q 1 of dietary fish intake). Similar findings were observed in multivariable models and in subgroup analyses. In a large cohort of healthy women, we found no evidence of an association between fish or omega-3 fatty acid intake and incident AF.
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