A shift in sensory processing that enables the developing human brain to discriminate touch from pain.
A shift in sensory processing that enables the developing human brain to discriminate touch from pain.
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DOI：
10.1016/j.cub.2011.08.010
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发表时间：
2011-09-27
期刊：
影响因子：
9.2
通讯作者：
Fitzgerald, Maria
中科院分区：
文献类型：
--
作者：
Fabrizi, Lorenzo;Slater, Rebeccah;Worley, Alan;Meek, Judith;Boyd, Stewart;Olhede, Sofia;Fitzgerald, Maria
婴儿何时以及如何开始区分有害刺激和无害刺激是神经科学中的一个基本问题。然而，鲜为人知的是，在完整的人类大脑的必要皮层体感功能的先决条件的发展。最近的研究发展中的脑网络强调的重要性，短暂的自发和诱发的神经元爆发活动的功能回路的形成。这些神经元爆发出现在发育过程中，并先于感觉功能的开始。因此，它们的消失和更像成年人的活动的出现被认为是功能性大脑回路成熟的信号。在这里，我们显示了神经元活动的变化模式，在早产儿的伤害性感受和触摸歧视的发病基础。我们进行了非侵入性脑电图（EEG）记录的大脑神经元活动的时间锁定触摸和临床上重要的有毒长矛的脚跟在28-45周的婴儿怀孕。我们发现，在触觉和伤害性刺激后，从非特异性的，均匀分散的神经元爆发到特定的，局部的，诱发电位的脑反应的过渡。结果表明，在人类大脑中，区分触摸和伤害感受所需的特定神经回路从妊娠35-37周开始出现。人的大脑可以从35-37周的妊娠区分触摸和疼痛。在35-37周之前，触摸和伤害性长矛引起非特异性神经元爆发。在35-37周之后，触摸和伤害性长矛引起模态特异性电位。
When and how infants begin to discriminate noxious from innocuous stimuli is a fundamental question in neuroscience. However, little is known about the development of the necessary cortical somatosensory functional prerequisites in the intact human brain. Recent studies of developing brain networks have emphasized the importance of transient spontaneous and evoked neuronal bursting activity in the formation of functional circuits. These neuronal bursts are present during development and precede the onset of sensory functions. Their disappearance and the emergence of more adult-like activity are therefore thought to signal the maturation of functional brain circuitry. Here we show the changing patterns of neuronal activity that underlie the onset of nociception and touch discrimination in the preterm infant. We have conducted noninvasive electroencephalogram (EEG) recording of the brain neuronal activity in response to time-locked touches and clinically essential noxious lances of the heel in infants aged 28–45 weeks gestation. We show a transition in brain response following tactile and noxious stimulation from nonspecific, evenly dispersed neuronal bursts to modality-specific, localized, evoked potentials. The results suggest that specific neural circuits necessary for discrimination between touch and nociception emerge from 35–37 weeks gestation in the human brain. ► The human brain may discriminate touch from pain from 35–37 weeks gestation ► Before 35–37 weeks, touch and noxious lance evoke nonspecific neuronal bursts ► After 35–37 weeks, touch and noxious lance evoke modality-specific potentials
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影响因子：
168.9
作者：
Slater, Rebeccah;Cornelissen, Laura;Fitzgerald, Maria
通讯作者：
Fitzgerald, Maria
影响因子：
3.6
作者：
Slater, Rebeccah;Worley, Alan;Fitzgerald, Maria
通讯作者：
Fitzgerald, Maria
影响因子：
64.8
作者：
Khazipov, R;Sirota, A;Buzsáki, G
通讯作者：
Buzsáki, G
DOI：
10.1016/0013-4694(73)90249-6
发表时间：
1973-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HRBEK, A;KARLBERG, P;OLSSON, T
通讯作者：
OLSSON, T
DOI：
10.1016/0013-4694(69)90006-6
发表时间：
1969-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HRBEK, A;HRBKOVA, M;LENARD, HG
通讯作者：
LENARD, HG