Worry is associated with impaired gating of threat from working memory.
Worry is associated with impaired gating of threat from working memory.
复制标题
DOI：
10.1037/emo0000015
复制
发表时间：
2015-02
期刊：
影响因子：
4.2
通讯作者：
Larson, Christine L.
中科院分区：
文献类型：
--
作者：
Stout, Daniel M.;Shackman, Alexander J.;Johnson, Jeffrey S.;Larson, Christine L.
性格性焦虑是焦虑和其他情绪障碍发展的一个公认的危险因素。这些疾病很常见、使人衰弱且治疗起来具有挑战性，这表明需要了解导致风险升高的更基本的神经认知机制。重要的是，许多焦虑特有的适应不良行为，例如担心，都是在威胁不存在时发生的。这提出了一种可能性，即担忧反映了从工作记忆中控制与威胁相关的信息的困难，工作记忆是支持信息维护、回忆和操作的有限容量工作空间，并促进目标导向的思想和行动。在这里，我们首次测试了焦虑表型的一个关键方面——担忧方面的特质状个体差异是否反映了从工作记忆中控制威胁和中性相关干扰因素的困难。结果表明，性格担忧和焦虑都可以单独预测威胁和中性干扰因素的综合过滤成本。重要的是，担忧与对工作记忆中与威胁相关但非中性干扰的低效过滤有关。相比之下，性格焦虑与类似水平的威胁和中立过滤成本相关。此外，性格焦虑与威胁过滤的关系主要是由担忧的差异驱动的。这些结果表明，忧虑倾向的特点是无法从工作记忆中排除与任务无关的威胁。这些结果为理解慢性担忧的机制以及更广泛的性格性焦虑的认知结构提供了一个框架。
Dispositional anxiety is a well-established risk factor for the development of anxiety and other emotional disorders. These disorders are common, debilitating, and challenging to treat, pointing to the need to understand the more elementary neurocognitive mechanisms that confer elevated risk. Importantly, many of the maladaptive behaviors characteristic of anxiety, such as worry, occur when threat is absent. This raises the possibility that worry reflects difficulties gating threat-related information from working memory, a limited capacity workspace that supports the maintenance, recall, and manipulation of information, and facilitates goal-directed thoughts and actions. Here, we tested for the first time whether trait-like individual differences in worry, a key facet of the anxious phenotype, reflect difficulties gating threat and neutral-related distracters from working memory. Results indicated that both dispositional worry and anxiety individually predicted the combined filtering cost of threat and neutral distracters. Importantly, worry was associated with inefficient filtering of threat-related but not neutral distracters from working memory. In contrast, dispositional anxiety was related to a similar level of threat and neutral filtering cost. Furthermore, dispositional anxiety’s relationship to filtering of threat was predominantly driven by differences in worry. These results suggest that the propensity to worry is characterized by a failure to gate task-irrelevant threat from working memory. These results provide a framework for understanding the mechanisms underlying chronic worry and more broadly, the cognitive architecture of dispositional anxiety.
登录
查看更多内容
影响因子：
18.4
作者：
Newman MG;Llera SJ;Erickson TM;Przeworski A;Castonguay LG
通讯作者：
Castonguay LG
影响因子：
3.7
作者：
Owens, Max;Koster, Ernst H. W.;Derakshan, Nazanin
通讯作者：
Derakshan, Nazanin
影响因子：
3.1
作者：
Kessler, Ronald C.;Petukhova, Maria;Sampson, Nancy A.;Zaslavsky, Alan M.;Wittchen, Hans-Ullrich
通讯作者：
Wittchen, Hans-Ullrich
影响因子：
64.8
作者：
Collins, Pamela Y.;Patel, Vikram;Joestl, Sarah S.;March, Dana;Insel, Thomas R.;Daar, Abdallah S.
通讯作者：
Daar, Abdallah S.
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF