Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes.
Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes.
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DOI：
10.1117/1.3078803
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发表时间：
2009-03
影响因子：
3.5
通讯作者：
Chen WR
中科院分区：
文献类型：
--
作者：
Zhou F;Xing D;Ou Z;Wu B;Resasco DE;Chen WR
单壁碳纳米管（SWNT）在近红外（NIR）区域具有高吸光率。在这种特殊的光学窗口中，生物系统是高度透明的。单壁碳纳米管的光学性质为选择性光热疗法用于癌症治疗提供了机会。具体而言，具有均匀尺寸（约0.81 nm）和在980 nm处的窄吸收峰的CoMoCAT®纳米管是这种新方法的理想候选者。在这里，CoMoCAT® SWNT与叶酸结合，叶酸可以特异性结合叶酸受体肿瘤标志物的表面。叶酸-单壁碳纳米管（FA-SWNT）靶向肿瘤细胞照射980 nm激光。在我们的体外和体内实验中，FA-SWNT有效地增强了对肿瘤细胞的光热破坏，并明显地避免了对非靶向正常细胞的光热破坏。因此，单壁碳纳米管，结合合适的肿瘤标记物，可以用作新型纳米材料的选择性光热治疗癌症的治疗。
Single-walled carbon nanotubes (SWNTs) have a high optical absorbance in the near-infrared (NIR) region. In this special optical window, biological systems are known to be highly transparent. The optical properties of SWNTs provide an opportunity for selective photothermal therapy for cancer treatment. Specifically, CoMoCAT® nanotubes with a uniform size (about 0.81 nm) and a narrow absorption peak at 980 nm are ideal candidates for such a novel approach. Here, CoMoCAT® SWNTs are conjugated to folate, which can bind specifically to the surface of the folate receptor tumor markers. Folate-SWNT (FA-SWNT) targeted tumor cells were irradiated by a 980-nm laser. In our in vitro and in vivo experiments, FA-SWNT effectively enhanced the photothermal destruction on tumor cells and noticeably spared the photothermal destruction for nontargeted normal cells. Thus, SWNTs, combined with suitable tumor markers, can be used as novel nanomaterials for selective photothermal therapy for cancer treatment.
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影响因子：
56.9
作者：
O'Connell, MJ;Bachilo, SM;Smalley, RE
通讯作者：
Smalley, RE
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
38.3
作者：
Porter, Alexandra E.;Gass, Mhairi;Welland, Mark
通讯作者：
Welland, Mark
影响因子：
4.7
作者：
Bagnoli, M;Canevari, S;Miotti, S
通讯作者：
Miotti, S
DOI：
10.1073/pnas.0837064100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Chen, RJ;Bangsaruntip, S;Dai, HJ
通讯作者：
Dai, HJ