Association of Dietary Vitamin C Consumption with Serum Klotho Concentrations.
Association of Dietary Vitamin C Consumption with Serum Klotho Concentrations.
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DOI：
10.3390/foods12234230
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发表时间：
2023-11-23
期刊：
影响因子：
5.2
通讯作者：
Xiao, Lin
中科院分区：
文献类型：
--
作者：
Wang, Yan;Wu, Mingyang;Xiang, Lu;Liu, Si;Luo, Gang;Lin, Qian;Xiao, Lin
背景：Klotho被广泛认为是一种抗衰老和具有抗氧化特性的蛋白质，这与许多疾病的病理生理有关。越来越多的证据表明，膳食营养素的摄入，特别是那些富含抗氧化剂的营养素，可能与血清克洛索浓度有关。膳食维生素C是具有抗氧化特性的重要营养素之一。尽管如此，膳食维生素C摄入量与血清克洛索浓度之间的关系仍不清楚。目的：为了评估40 - 79岁美国人血清Klotho浓度与膳食维生素C摄入量之间的关系，我们进行了一项基于人群的研究。方法：从2007年至2016年进行的国家健康与营养检查调查（NHANES）中，总共选择了11,282名符合标准的个体作为研究的合格参与者。使用市售的ELISA试剂盒测定血清Klotho浓度。训练有素的采访者通过24小时饮食回忆技术评估饮食中维生素C的摄入量。采用广义线性模型评价饲粮中维生素C摄入量与血清克洛索浓度之间的相关性。采用限制性三次样条（RCS）分析进一步探讨日粮中维生素C摄入量与血清克洛索浓度之间的非线性关系。结果：在考虑可能的混杂因素后，随着膳食维生素C摄入量的每一个标准差（SD）的升高，血清Klotho浓度升高1.17%（95%置信区间：0.37%,1.99%）。以第1个五分位数为参照，血清Klotho浓度在第5个五分位数的变化百分比高3.66% （95% CI: 1.05%, 6.32%）。在年龄较大、体重正常的男性参与者中，亚组分析显示，膳食维生素C摄入量与血清克洛索浓度之间存在更强的相关性。RCS分析显示，膳食维生素C摄入量与血清Klotho浓度水平呈线性正相关。结论：本研究结果表明，在美国普通成年人中，膳食维生素C摄入量与血清Klotho浓度之间存在强烈的正相关关系。需要进一步的研究来验证目前的发现并探索具体的机制。
Background: Klotho is widely recognized as a protein that combats aging and possesses antioxidative characteristics, which have been implicated in the pathophysiology of numerous diseases. There is emerging evidence suggesting that the consumption of dietary nutrients, particularly those rich in antioxidants, could be associated with serum Klotho concentrations. Dietary vitamin C is one of the critical nutrients that possesses antioxidant properties. Nonetheless, the association between dietary vitamin C consumption and serum Klotho concentrations remains unclear. Objective: Aiming to evaluate the relationship between serum Klotho concentrations and dietary vitamin C consumption among Americans aged 40 to 79, we conducted a population-based study. Methods: From the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2016, a grand total of 11,282 individuals who met the criteria were selected as eligible participants for the study. Serum Klotho concentrations were measured using an ELISA kit that is commercially available. Trained interviewers evaluated the consumption of dietary vitamin C in the diet through a 24-hour dietary recall technique. A generalized linear model was used to evaluate the correlation between the consumption of dietary vitamin C in the diet and serum Klotho concentrations. Further examination was conducted using restricted cubic spline (RCS) analysis to explore the non-linear correlation between dietary vitamin C consumption in the diet and serum Klotho concentrations. Results: After accounting for possible confounding factors, serum Klotho concentrations rose by 1.17% (95% confidence interval (CI): 0.37%, 1.99%) with every standard deviation (SD) rise in dietary vitamin C consumption. With the first quintile of dietary vitamin C consumption as a reference, the percentage change of serum Klotho concentrations in the fifth quintile of dietary vitamin C consumption was 3.66% higher (95% CI: 1.05%, 6.32%). In older, normal-weight, and male participants, the subgroup analysis revealed a stronger correlation between dietary vitamin C consumption and serum Klotho concentrations. Analysis of RCS showed a linear positive association between dietary vitamin C consumption and the levels of serum Klotho concentrations. Conclusion: The findings of this research indicate a strong and positive correlation between dietary vitamin C consumption and serum Klotho concentrations among the general adult population in the United States. Further studies are needed to validate the present findings and to explore specific mechanisms.
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