Actigraphy-based sleep characteristics and aortic stiffness: the Multi-Ethnic Study of Atherosclerosis.

Actigraphy-based sleep characteristics and aortic stiffness: the Multi-Ethnic Study of Atherosclerosis.
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基于积极的睡眠特征和主动脉僵硬:动脉粥样硬化的多种族研究。

DOI:
10.1016/j.jash.2018.09.008
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发表时间:
2018-12
期刊:
Journal of the American Society of Hypertension : JASH
影响因子:
--
通讯作者:
Kwon Y
Kwon Y
中科院分区:
其他
文献类型:
--
作者:
Logan JG;Kang H;Lobo JM;Sohn MW;Lin GM;Lima JAC;Punjabi NM;Redline S;Kwon Y

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该研究旨在根据睡眠持续时间和质量以及主动脉僵硬度的客观估计来检验这种关联,同时考虑到 SDB 的潜在混杂效应。参与者是动脉粥样硬化多种族研究 (MESA) 睡眠研究的一部分。通过 7 天腕部活动记录仪评估睡眠持续时间和质量,通过家庭多导睡眠图评估 SDB,通过基于磁共振成像 (MRI) 的主动脉脉搏波速度 (aPWV)、升主动脉和降主动脉扩张性(AAD 和 DAD)评估主动脉僵硬度。将“正常”睡眠时间(6-8 小时)参与者的主动脉僵硬度与“短”睡眠时间(<6 小时)和“长”睡眠时间(>8 小时)的参与者进行比较,并根据常见心血管危险因素和呼吸暂停低通气指数 (AHI) 进行调整。样本由 908 名参与者组成(平均年龄 68.4±9.1 岁,55.3% 为女性)。在短睡眠时间 (n=252)、正常睡眠时间 (n=552) 和长睡眠时间 (n=104) 中,aPWV 的增加呈显着线性趋势(趋势 p=0.008)。多变量分析显示,与睡眠时间正常的人相比,睡眠时间短的人的 aPWV 低 0.94 m/s(95% CI:-1.54,-0.35)。在这个种族多样化的社区队列中,通过体动记录仪估计的习惯性短睡眠时间与较低的主动脉僵硬度相关。
The study aimed to examine the association based on objective estimates of sleep duration and quality and aortic stiffness while accounting for the potential confounding effect of SDB. Participants were part of the Multi-Ethnic Study of Atherosclerosis (MESA) Sleep study. Sleep duration and quality were assessed by 7-day wrist actigraphy, SDB by home polysomnography, and aortic stiffness by magnetic resonance imaging (MRI)-based aortic pulse wave velocity (aPWV), ascending and descending aorta distensibility (AAD and DAD). Aortic stiffness of participants with ‘normal’ sleep duration (6–8 hours) were compared with those of ‘short’ (<6 hours) and ‘long’ sleep duration (>8 hours) adjusting for common cardiovascular risk factors and apnea hypopnea index (AHI). The sample consisted of 908 participants (mean age 68.4±9.1 years, 55.3% female). There was a significant linear trend of increased aPWV across short (n=252), normal (n=552), and long sleep durations (n=104) (p for trend=0.008). Multivariable analysis showed that people with short sleep duration had 0.94 m/s lower aPWV (95% CI: −1.54, −0.35), compared with those with normal sleep duration. In this ethnically diverse community cohort, habitual short sleep duration as estimated by actigraphy was associated with lower aortic stiffness.
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