Cerebral amyloid angiopathy pathology and cognitive domains in older persons.
Cerebral amyloid angiopathy pathology and cognitive domains in older persons.
复制标题
DOI：
10.1002/ana.22112
复制
发表时间：
2011-02
影响因子：
11.2
通讯作者：
Schneider, Julie A.
中科院分区：
文献类型：
--
作者：
Arvanitakis, Zoe;Leurgans, Sue E.;Wang, Zhenxin;Wilson, Robert S.;Bennett, David A.;Schneider, Julie A.
研究社区老年痴呆患者和非痴呆患者脑淀粉样血管病（CAA）与认知功能的关系。受试者是404人在宗教秩序研究，队列研究的老化，谁进行年度临床评估，包括19个神经心理测试，从5个认知领域和全球总结得分，并在死亡时脑尸检（平均死亡年龄86岁）。使用淀粉样蛋白-β免疫染色，CAA严重程度在5个区域（中额、下颞、角、距状核和海马皮质）分级，0 =无，1 =轻度，2 =中度，3 =重度，4 =非常严重。由于严重程度在不同地区之间存在相关性（所有rs > 0.63），并且几乎所有人都有一定程度的CAA，因此我们对地区CAA评分进行了平均，并创建了无至最小（<0.5）、轻度至中度（0.5-2.5）和中度至非常严重（>2.5）CAA的类变量预测因子。CAA非常常见（84.9%; 94例为无至极轻微，233例为轻度至中度，76例为中度至极重度疾病），与AD病理学相关（rs = 0.68）。在控制年龄、性别、教育、AD病理、梗死和路易体的线性回归分析中，中度至极重度CAA与较低的感知速度（p = 0.012）和情景记忆（p = 0.047）相关，但与语义记忆、工作记忆、视觉空间技能或所有认知测量的复合物无关。没有发现轻度到中度CAA与认知能力之间的联系，痴呆症也没有改变这些发现。CAA病理在老年社区居民中非常常见，并与AD病理相关。中度至非常重度CAA，而不是轻度至中度CAA，与特定认知领域的较低表现相关，最明显的是感知速度，与AD病理学的影响无关。
To examine the relation of cerebral amyloid angiopathy (CAA) to cognitive domains in older community-dwelling persons with and without dementia. Subjects were 404 persons in the Religious Orders Study, a cohort study of aging, who underwent annual clinical evaluations, including 19 neuropsychological tests from which 5 cognitive domain and global summary scores were derived, and brain autopsy at time-of-death (mean age-at-death 86). Using amyloid-β immunostaining, CAA severity was graded in 5 regions (midfrontal, inferior temporal, angular, calcarine, and hippocampal cortices), as 0 = none, 1 = mild, 2 = moderate, 3 = severe, and 4 = very severe. Because severity was related across regions (all rs > 0.63), and almost all persons had some CAA, we averaged regional CAA scores and created class variable predictors for no-to-minimal (<0.5), mild-to-moderate (0.5-2.5) and moderate-to-very severe CAA (>2.5). CAA was very common (84.9%; 94 had no-to-minimal, 233 mild-to-moderate, and 76 moderate-to-very severe disease) and was related to AD pathology (rs = 0.68). In linear regression analyses controlling for age, sex, education, AD pathology, infarcts, and Lewy bodies, moderate-to-very severe CAA was associated with lower perceptual speed (p = 0.012) and episodic memory (p = 0.047), but not semantic memory, working memory, visuospatial skills, or a composite of all cognitive measures. No associations of mild-to-moderate CAA with cognition were found. Dementia did not modify these findings. CAA pathology is very common in older community-dwelling persons and is associated with AD pathology. Moderate-to-very severe CAA, but not mild-to-moderate CAA, is associated with lower performance in specific cognitive domains, most notably perceptual speed, separately from the effect of AD pathology.
登录
查看更多内容
痴呆症的流行病学病理：医学研究委员会认知功能和衰老研究中死亡的可归因风险。
影响因子：
15.8
作者：
Matthews FE;Brayne C;Lowe J;McKeith I;Wharton SB;Ince P
通讯作者：
Ince P
影响因子：
8.3
作者：
Holland, Christopher M.;Smith, Eric E.;Greenberg, Steven M.
通讯作者：
Greenberg, Steven M.
影响因子：
48
作者：
Greenberg, Steven M.;Vernooij, Meike W.;Cordonnier, Charlotte;Viswanathan, Anand;Salman, Rustorn Al-Shahi;Warach, Steven;Launer, Lenore J.;Van Buchem, Mark A.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
影响因子：
8.3
作者：
Jeerakathil, T;Wolf, PA;DeCarli, C
通讯作者：
DeCarli, C
影响因子：
9.9
作者：
Bennett, DA;Wilson, RS;Bienias, JL
通讯作者：
Bienias, JL