Structural biology data archiving - where we are and what lies ahead.
Structural biology data archiving - where we are and what lies ahead.
复制标题
DOI：
10.1002/1873-3468.13086
复制
发表时间：
2018-06
期刊：
影响因子：
3.5
通讯作者：
Patwardhan A
中科院分区：
文献类型：
--
作者：
Kleywegt GJ;Velankar S;Patwardhan A
近50年来，结构生物学一直致力于通过蛋白质数据库、电子显微镜数据库和生物磁共振数据库(BMRB)等全球公共档案保存和共享其实验数据及其解释(通常是原子模型)。这些档案是免费访问的数据宝库，记录了我们对健康和疾病中生物功能和过程的分子或原子理解的追求。随着越来越多的技术(组合)被用来在不断增长的长度尺度上阐明结构，他们已经为应对新的归档挑战做好了准备。此外，外地已作出重大努力，制定验证方法，帮助用户评估结构的可靠性，并确定最适合其需要的数据。在这篇综述中，我们概述了结构生物学中的公共数据档案，并讨论了验证对结构数据的使用者和生产者的重要性。最后，我们概述了我们将结构数据与生物成像数据以及其他生物数据来源相结合的努力。这将使相关的结构信息可用，并更容易被广泛的科学家发现。
For almost 50 years, structural biology has endeavoured to conserve and share its experimental data and their interpretations (usually, atomistic models) through global public archives such as the Protein Data Bank, Electron Microscopy Data Bank and Biological Magnetic Resonance Data Bank (BMRB). These archives are treasure troves of freely accessible data that document our quest for molecular or atomic understanding of biological function and processes in health and disease. They have prepared the field to tackle new archiving challenges as more and more (combinations of) techniques are being utilized to elucidate structure at ever increasing length scales. Furthermore, the field has made substantial efforts to develop validation methods that help users to assess the reliability of structures and to identify the most appropriate data for their needs. In this Review, we present an overview of public data archives in structural biology and discuss the importance of validation for users and producers of structural data. Finally, we sketch our efforts to integrate structural data with bioimaging data and with other sources of biological data. This will make relevant structural information available and more easily discoverable for a wide range of scientists.
登录
查看更多内容
影响因子：
14.9
作者：
Federhen S
通讯作者：
Federhen S
影响因子：
14.9
作者：
Kalvari I;Argasinska J;Quinones-Olvera N;Nawrocki EP;Rivas E;Eddy SR;Bateman A;Finn RD;Petrov AI
通讯作者：
Petrov AI
DOI：
10.1016/j.str.2017.10.009
发表时间：
2017-12-05
期刊：
Structure (London, England : 1993)
影响因子：
--
作者：
Gore S;Sanz García E;Hendrickx PMS;Gutmanas A;Westbrook JD;Yang H;Feng Z;Baskaran K;Berrisford JM;Hudson BP;Ikegawa Y;Kobayashi N;Lawson CL;Mading S;Mak L;Mukhopadhyay A;Oldfield TJ;Patwardhan A;Peisach E;Sahni G;Sekharan MR;Sen S;Shao C;Smart OS;Ulrich EL;Yamashita R;Quesada M;Young JY;Nakamura H;Markley JL;Berman HM;Burley SK;Velankar S;Kleywegt GJ
通讯作者：
Kleywegt GJ
影响因子：
5.7
作者：
Adams, Paul D.;Aertgeerts, Kathleen;Bauer, Cary;Bell, Jeffrey A.;Berman, Helen M.;Bhat, Talapady N.;Blaney, Jeff M.;Bolton, Evan;Bricogne, Gerard;Brown, David;Burley, Stephen K.;Case, David A.;Clark, Kirk L.;Darden, Tom;Emsley, Paul;Feher, Victoria A.;Feng, Zukang;Groom, Colin R.;Harris, Seth F.;Hendle, Jorg;Holder, Thomas;Joachimiak, Andrzej;Kleywegt, Gerard J.;Krojer, Tobias;Marcotrigiano, Joseph;Mark, Alan E.;Markley, John L.;Miller, Matthew;Minor, Wladek;Montelione, Gaetano T.;Murshudov, Garib;Nakagawa, Atsushi;Nakamura, Haruki;Nicholls, Anthony;Nicklaus, Marc;Nolte, Robert T.;Padyana, Anil K.;Peishoff, Catherine E.;Pieniazek, Susan;Read, Randy J.;Shao, Chenghua;Sheriff, Steven;Smart, Oliver;Soisson, Stephen;Spurlino, John;Stouch, Terry;Svobodova, Radka;Tempel, Wolfram;Terwilliger, Thomas C.;Tronrud, Dale;Velankar, Sameer;Ward, Suzanna C.;Warren, Gregory L.;Westbrook, John D.;Williams, Pamela;Yang, Huanwang;Young, Jasmine
通讯作者：
Young, Jasmine
蛋白质 - 一种科学的“ Wiki”，桥接了三维结构和生物分子的功能之间的裂痕。
影响因子：
12.3
作者：
Hodis, Eran;Prilusky, Jaime;Martz, Eric;Silman, Israel;Moult, John;Sussman, Joel L.
通讯作者：
Sussman, Joel L.