Simultaneous multiwavelength laminar optical tomography.

Simultaneous multiwavelength laminar optical tomography.
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同时进行多波长层状光学断层扫描。

DOI:
10.1364/ol.33.002710
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发表时间:
2008-11-15
期刊:
影响因子:
3.6
通讯作者:
Hillman EM
Hillman EM
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Burgess SA;Bouchard MB;Yuan B;Hillman EM

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空间分辨反射率测量可用于表征浅表组织的深度分辨光学特性。然而,到目前为止,多波长数据的快速采集一直受到多路复用问题的阻碍。我们报告了一种新的多波长层流光学层析成像系统,能够同时在三个波长处从多个源检测器分离获取数据。这样的数据可以允许吸收体(例如氧合血红蛋白和脱氧血红蛋白)或多个荧光团的体内深度分辨光谱成像,其在超过100 Hz的帧速率下不受运动伪影的影响。介绍了系统设计和体模验证研究。
Spatially resolved reflectance measurements can be used to characterize the depth-resolved optical properties of superficial tissues. However, until now, rapid acquisition of multiwavelength data has been hindered by multiplexing problems. We report on a novel multiwavelength laminar optical tomography system capable of acquiring data from multiple source-detector separations at three wavelengths simultaneously. Such data can allow in vivo depth-resolved spectroscopic imaging of absorbers, such as oxy- and deoxyhemoglobin, or of multiple fluorophores, that is unaffected by motion artifacts at frame rates exceeding 100 Hz. The system design and phantom validation studies are presented.
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