Dynamics of intrapericardial and extrapericardial fat tissues during long-term, dietary-induced, moderate weight loss.
Dynamics of intrapericardial and extrapericardial fat tissues during long-term, dietary-induced, moderate weight loss.
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长期饮食诱导的适度减肥期间心包内和心包外脂肪组织的动态。
DOI：
10.3945/ajcn.117.157115
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
I. Shai
中科院分区：
文献类型：
--
作者：
G. Tsaban;A. Wolak;Hila Avni;Y. Gepner;I. Shelef;Y. Henkin;D. Schwarzfuchs;Noa Cohen;Nitzan Bril;Michal Rein;D. Serfaty;Shira Kenigsbuch;L. Tene;H. Zelicha;A. Yaskolka;O. Komy;Avital Bilitzky;Yoash Chassidim;U. Ceglarek;M. Stumvoll;M. Blüher;J. Thiery;D. Dicker;A. Rudich;M. Stampfer;I. Shai
背景资料：鉴于心包脂肪堆积与心血管疾病风险增加有关的证据，需要采取减少其负担的策略。比较特定的长期饮食干预对心包脂肪组织动员的影响的数据很少。目的：我们试图评估不同饮食方案减肥干预期间心包内脂肪（IPF）和心包外脂肪（EPF）的变化。设计：在18个月的随机对照试验中，我们在随机分配的中度腹部肥胖受试者中比较了地中海/低碳水化合物（MED/LC）饮食加28 g核桃/d与热量相等的低脂（LF）饮食。我们对80名参与者进行了全身MRI和体积定量IPF和EPF，以跟踪18个月的变化。结果：参与者[平均年龄：48.6岁;平均体重指数（BMI; kg/m2）; 31.7; 90%男性]的基线IPF和EPF（平均值± SD）体积分别为172.4 ± 53.3 mL和194.9 ± 71.5 mL。两组的18个月中度体重减轻（3.7 kg）相似，但MED/LC组的腰围减少（-6.9 ± 6.6 cm）高于LF饮食组（-2.3 ± 6.5 cm; P = 0.01）。18个月后，MED/LC组的IPF体积比LF组减少两倍[分别为-37 ± 26.2 mL（-22% ± 15%）和-15.5 ± 26.2 mL（-8% ± 15%）; P < 0.05，校正体重或内脏脂肪组织变化后]。两组的EPF体积减少相似[MED/LC组为-41.6 ± 30.2 mL（-23% ± 16%），LF组为-37.9 ± 28.3 mL（-19% ± 14%）; P > 0.1]。在控制体重减轻后，IPF和EPF减容抑制了血脂谱的变化，但未改善血糖谱变量：IPF相对降低与甘油三酯（TG）降低相关（β = 0.090; 95%CI：0.026，0.154; P = 0.007）及TG/HDL比值（β = 2.689; 95%CI：0.373，5.003; P = 0.024），EPF相对降低与HDL胆固醇升高相关（β = -0.452; 95% CI：-0.880，-0.023; P = 0.039）和总胆固醇和HDL胆固醇降低（β = 3.766; 95%CI：1.092，6.440; P = 0.007）。结论：中度但持续的饮食诱导的体重减轻显著降低了IPF和EPF体积。心包脂肪组织减少与血脂改善独立相关。地中海饮食富含不饱和脂肪和限制性碳水化合物，在减轻IPF负担方面优于LF饮食上级。本试验在clinicaltrials.gov上注册为NCT 01530724。
Background: In view of evidence linking pericardial fat accumulation with increased cardiovascular disease risk, strategies to reduce its burden are needed. Data comparing the effects of specific long-term dietary interventions on pericardial fat tissue mobilization are sparse.Objective: We sought to evaluate intrapericardial-fat (IPF) and extrapericardial-fat (EPF) changes during weight-loss interventions by different dietary regimens.Design: During 18 mo of a randomized controlled trial, we compared a Mediterranean/low-carbohydrate (MED/LC) diet plus 28 g walnuts/d with a calorically equal low-fat (LF) diet among randomly assigned participants with moderate abdominal obesity. We performed whole-body MRI and volumetrically quantified IPF and EPF among 80 participants to follow the 18-mo changes.Results: The participants [mean age: 48.6 y; mean body mass index (BMI; in kg/m2); 31.7; 90% men] had baseline IPF and EPF (mean ± SD) volumes of 172.4 ± 53.3 mL and 194.9 ± 71.5 mL, respectively. The 18-mo moderate weight loss of 3.7 kg was similar in both groups, but the reduction in waist circumference was higher in the MED/LC group (-6.9 ± 6.6 cm) than in the LF diet group (-2.3 ± 6.5 cm; P = 0.01). After 18 mo, the IPF volume had reduced twice as much in the MED/LC group compared with the LF group [-37 ± 26.2 mL (-22% ± 15%) compared with -15.5 ± 26.2 mL (-8% ± 15%), respectively; P < 0.05, after adjustment for changes in weight or visceral adipose tissue]. The EPF volume had reduced similarly in both groups [-41.6 ± 30.2 mL (-23% ± 16%) in the MED/LC group compared with -37.9 ± 28.3 mL (-19% ± 14%) in the LF group; P > 0.1]. After controlling for weight loss, IPF and EPF volume reduction paralleled changes in lipid profile but not with improved glycemic profile variables: the IPF relative reduction was associated with a decrease in triglycerides (TGs) (β = 0.090; 95% CI: 0.026, 0.154; P = 0.007) and the ratio of TGs to high-density lipoprotein (HDL) cholesterol (β = 2.689; 95% CI: 0.373, 5.003; P = 0.024), and the EPF relative reduction was associated with an increase in HDL cholesterol (β = -0.452; 95% CI: -0.880, -0.023; P = 0.039) and a decrease in total cholesterol and HDL cholesterol (β = 3.766; 95% CI: 1.092, 6.440; P = 0.007).Conclusions: Moderate but persistent dietary-induced weight loss substantially decreased both IPF and EPF volumes. Reduction of pericardial adipose tissues is independently associated with an improved lipid profile. The Mediterranean diet, rich in unsaturated fats and restricted carbohydrates, is superior to an LF diet in terms of the IPF burden reduction. This trial was registered at clinicaltrials.gov as NCT01530724.
影响因子：
7.1
作者：
Ding, Jingzhong;Hsu, Fang-Chi;Carr, J. Jeffrey
通讯作者：
Carr, J. Jeffrey
影响因子：
39.3
作者：
Mahabadi, Amir A.;Massaro, Joseph M.;Hoffmann, Udo
通讯作者：
Hoffmann, Udo
影响因子：
24
作者：
Cannone, Valentina;Boerrigter, Guido;Cataliotti, Alessandro;Costello-Boerrigter, Lisa C.;Olson, Timothy M.;McKie, Paul M.;Heublein, Denise M.;Lahr, Brian D.;Bailey, Kent R.;Averna, Maurizio;Redfield, Margaret M.;Rodeheffer, Richard J.;Burnett, John C., Jr.
通讯作者：
Burnett, John C., Jr.