A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community.
A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community.
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DOI：
10.1016/j.jacc.2011.05.011
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发表时间：
2011-08-02
影响因子：
24
通讯作者：
Burnett, John C., Jr.
中科院分区：
文献类型：
--
作者：
Cannone, Valentina;Boerrigter, Guido;Cataliotti, Alessandro;Costello-Boerrigter, Lisa C.;Olson, Timothy M.;McKie, Paul M.;Heublein, Denise M.;Lahr, Brian D.;Bailey, Kent R.;Averna, Maurizio;Redfield, Margaret M.;Rodeheffer, Richard J.;Burnett, John C., Jr.
关键词：
我们试图定义与rs5068相关的心脏代谢表型，rs5068是心钠素(ANP)基因的遗传变异。心钠素和脑钠素在心肾内稳态中起重要作用，但也发挥代谢作用。我们对从美国明尼苏达州奥姆斯特县随机抽取的1608名居民进行了基因分型。受试者的特征都很好。AA型占89.9%，AG型占9.7%，GG型占0.4%，所有后续分析均为AA型vsAG+GG型。在调整了年龄和性别后，G等位基因与血浆N末端心钠素(NT-proANP)水平升高相关(p=0.002)。微小等位基因还与较低的体重指数(p=0.006)、肥胖率(p=0.002)、腰围(p=0.021)、较低的C-反应蛋白水平(p=0.027)和较高的高密度脂蛋白胆固醇值(p=0.019)相关。AG+GG组的收缩压较低(p=0.011)，心肌梗死发生率较低(p=0.042)。次要等位基因与较低的代谢综合征患病率相关(p=0.025)。校正BMI后，G等位基因与高密度脂蛋白、C反应蛋白、心肌梗死和代谢综合征的相关性不显著；即使调整NT-proANP后，G等位基因与收缩压、BMI、肥胖、腰围的相关性仍然显著。在美国普通人群的随机样本中，rs5068的次要等位基因与良好的心脏代谢谱相关。这些发现提示rs5068或连锁不平衡的遗传位点可能影响心脏代谢性疾病的易感性，并支持利钠肽可能通过对代谢功能的有利作用而发挥保护作用。需要进行复制研究来证实我们的发现。
We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene. ANP and BNP play an important role in cardiorenal homeostasis but also exert metabolic actions. We genotyped 1608 randomly selected residents from Olmsted County, Minnesota, USA. Subjects were well characterized. Genotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA vs AG+GG. After adjustment for age and gender the G allele was associated with increased plasma levels of N-terminal-proANP (NT-proANP) (p=0.002). The minor allele was also associated with lower BMI (p=0.006), prevalence of obesity (p=0.002), waist circumference (p=0.021), lower levels of C-reactive protein (p=0.027) and higher values of HDL cholesterol (p=0.019). The AG+GG group had a lower systolic blood pressure (p=0.011) and lower prevalence of myocardial infarction (p=0.042). The minor allele was associated with a lower prevalence of metabolic syndrome (p=0.025). After adjusting for BMI the association between the G allele and HDL cholesterol, C – reactive protein values, myocardial infarction and metabolic syndrome was not significant; the association with systolic blood pressure, BMI, obesity, waist circumference remained significant even after adjusting for NT-proANP. In a random sample of the general US population the minor allele of rs5068 is associated with a favorable cardiometabolic profile. These findings suggest that rs5068 or genetic loci in linkage disequilibrium may affect susceptibility for cardiometabolic diseases and support the possible protective role of natriuretic peptides by their favorable effects on metabolic function. Replication studies are needed to confirm our findings.
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影响因子：
7.7
作者：
Miyashita K;Itoh H;Tsujimoto H;Tamura N;Fukunaga Y;Sone M;Yamahara K;Taura D;Inuzuka M;Sonoyama T;Nakao K
通讯作者：
Nakao K
DOI：
10.1016/0006-291x(84)91077-5
发表时间：
1984-01-01
影响因子：
3.1
作者：
KANGAWA, K;MATSUO, H
通讯作者：
MATSUO, H
影响因子：
5.8
作者：
Birkenfeld, AL;Boschmann, M;Jordan, J
通讯作者：
Jordan, J
影响因子：
120.7
作者：
Redfield, MM;Jacobsen, SJ;Rodeheffer, RJ
通讯作者：
Rodeheffer, RJ
DOI：
10.1016/s0735-1097(02)02059-4
发表时间：
2002-09-04
影响因子：
24
作者：
Redfield, MM;Rodeheffer, RJ;Burnett, JC
通讯作者：
Burnett, JC