Timing, number, and type of sexual partners associated with risk of oropharyngeal cancer.
Timing, number, and type of sexual partners associated with risk of oropharyngeal cancer.
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DOI：
10.1002/cncr.33346
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发表时间：
2021-04-01
期刊：
影响因子：
6.2
通讯作者：
D'Souza G
中科院分区：
文献类型：
--
作者：
Drake VE;Fakhry C;Windon MJ;Stewart CM;Akst L;Hillel A;Chien W;Ha P;Miles B;Gourin CG;Mandal R;Mydlarz WK;Rooper L;Troy T;Yavvari S;Waterboer T;Brenner N;Eisele DW;D'Souza G
Case-control studies from the early 2000s demonstrated that HPV-related oropharyngeal cancer (HPV-OPC) is a distinct entity associated with number of oral sex partners. Using contemporary data, we investigated novel risk factors (sexual debut behaviors, exposure intensity, and relationship dynamics) and serological markers on odds of HPV-OPC. HPV-OPC patients and frequency-matched controls were enrolled in a multi-center study from 2013–2018. Participants completed a behavioral survey. Characteristics were compared using χ2 for categorical and t-test for continuous variables. Adjusted odds ratios (aOR) were calculated using logistic regression. 163 HPV-OPC cases and 345 controls were included. Lifetime number of oral sex partners was associated with significantly increased odds of HPV-OPC (>10 partners, odds ratio[OR]=4.3, 95% confidence interval[CI]=2.8–6.7). After adjustment for number of oral sex partners and smoking, younger age at first oral sex (<18 vs.>20 years, aOR=1.8, 95% CI=1.1–3.2) and oral sex intensity (>5 sex-years, aOR=2.8, 95% CI=1.1–7.5) remained associated with significantly increased odds of HPV-OPC. Type of sexual partner such as older partners when a case was younger (OR=1.7, 95% CI=1.1–2.6) or having a partner who had extramarital sex (OR=1.6, 95% CI=1.1–2.4) was associated with HPV-OPC. Seropositivity for antibodies to HPV16 E6 (OR=286, 95% CI=122–670) and any HPV16 E protein (E1,E2,E6,E7; OR=163, 95% CI=70–378) was associated with increased odds of HPV-OPC. Number of oral sex partners remains a strong risk factor for HPV-OPC, however timing and intensity of oral sex are novel independent risk factors. These behaviors suggest additional nuances of how and why some individuals develop HPV-OPC. In this most comprehensive behavioral case-control study of HPV-related oropharyngeal cancer to date, ever performing oral sex and number of partners remain strong risk factors for HPV-related oropharyngeal cancer. Measures of oral sexual behavior including early age and intensity of exposure are independent risk factors, suggesting these behaviors may explain additional nuances of how and why some people develop HPV-related oropharyngeal cancer.
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DOI：
10.1038/npp.2017.198
发表时间：
2018-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Hasin DS
通讯作者：
Hasin DS
影响因子：
6.4
作者：
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通讯作者：
Franceschi S
影响因子：
5
作者：
Hickson, DeMarc A.;Mena, Leandro A.;Mayer, Kenneth H.
通讯作者：
Mayer, Kenneth H.
影响因子：
28.4
作者：
D'Souza G;Westra WH;Wang SJ;van Zante A;Wentz A;Kluz N;Rettig E;Ryan WR;Ha PK;Kang H;Bishop J;Quon H;Kiess AP;Richmon JD;Eisele DW;Fakhry C
通讯作者：
Fakhry C
DOI：
10.1158/1055-9965.epi-08-0845
发表时间：
2009-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Berthiller J;Lee YC;Boffetta P;Wei Q;Sturgis EM;Greenland S;Morgenstern H;Zhang ZF;Lazarus P;Muscat J;Chen C;Schwartz SM;Eluf Neto J;Wünsch Filho V;Koifman S;Curado MP;Matos E;Fernandez L;Menezes A;Daudt AW;Ferro G;Brennan P;Hashibe M
通讯作者：
Hashibe M