RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis.
RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis.
复制标题
DOI：
10.3389/fimmu.2021.664756
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Kantarci A
中科院分区：
文献类型：
--
作者：
Alvarez C;Abdalla H;Sulliman S;Rojas P;Wu YC;Almarhoumi R;Huang RY;Galindo M;Vernal R;Kantarci A
牙周炎是一种慢性炎症性疾病，与菌斑生物膜的形成有关，并以牙槽骨的进行性破坏为特征。从健康到疾病的转变的特征在于牙周免疫细胞组成的转变，从主要是先天性（中性粒细胞）到适应性（T淋巴细胞）免疫反应。Resolvin E1（RvE 1）是一种专门的促消退介质（SPM），在炎症反应中产生，以增强其消退。以前的研究表明RvE 1在牙周病中的治疗潜力;然而，RvE 1在微生物引起的破骨细胞生成免疫反应中的影响在体内仍然没有表征。在本研究中，我们研究了RvE 1对小鼠牙周炎模型中牙龈炎性浸润形成的影响。首先，我们通过流式细胞术表征了牙龈浸润的主要免疫细胞的时间依赖性变化。然后，我们评估了早期或延迟RvE 1给药对牙龈免疫浸润和颈部淋巴结组成的影响。我们观察到对T细胞-特别是效应T细胞-的一致抑制结果，以及对调节性T细胞（T细胞）的保护作用。我们的数据进一步证明了RvE 1的广泛作用，其在炎症过程中建立适应性免疫反应的预防作用，以及骨保护能力。
Periodontitis is a chronic inflammatory disease associated with the formation of dysbiotic plaque biofilms and characterized by the progressive destruction of the alveolar bone. The transition from health to disease is characterized by a shift in periodontal immune cell composition, from mostly innate (neutrophils) to adaptive (T lymphocytes) immune responses. Resolvin E1 (RvE1) is a specialized pro-resolution mediator (SPMs), produced in response to inflammation, to enhance its resolution. Previous studies have indicated the therapeutic potential of RvE1 in periodontal disease; however, the impact of RvE1 in the microbial-elicited osteoclastogenic immune response remains uncharacterized in vivo. In the present study, we studied the impact of RvE1 on the gingival inflammatory infiltrate formation during periodontitis in a mouse model. First, we characterized the temporal-dependent changes of the main immune cells infiltrating the gingiva by flow cytometry. Then, we evaluated the impact of early or delayed RvE1 administration on the gingival immune infiltration and cervical lymph nodes composition. We observed a consistent inhibitory outcome on T cells -particularly effector T cells- and a protective effect on regulatory T cells (Tregs). Our data further demonstrated the wide range of actions of RvE1, its preventive role in the establishment of the adaptive immune response during inflammation, and bone protective capacity.
登录
查看更多内容
影响因子：
1.3
作者：
Gyurko R;Van Dyke TE
通讯作者：
Van Dyke TE
影响因子：
3.2
作者：
Ling, Martin R.;Chapple, Iain L. C.;Matthews, John B.
通讯作者：
Matthews, John B.
影响因子：
4.6
作者：
Alvarez C;Rojas C;Rojas L;Cafferata EA;Monasterio G;Vernal R
通讯作者：
Vernal R
影响因子：
9
作者：
Marwick JA;Mills R;Kay O;Michail K;Stephen J;Rossi AG;Dransfield I;Hirani N
通讯作者：
Hirani N
影响因子：
3.1
作者：
Herrera, Bruno S.;Hasturk, Hatice;Van Dyke, Thomas E.
通讯作者：
Van Dyke, Thomas E.