Expression of connective tissue growth factor and interleukin-11 in intratumoral tissue is associated with poor survival after curative resection of hepatocellular carcinoma
Expression of connective tissue growth factor and interleukin-11 in intratumoral tissue is associated with poor survival after curative resection of hepatocellular carcinoma
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瘤内组织中结缔组织生长因子和白细胞介素11的表达与肝细胞癌根治性切除后的不良生存率相关
DOI：
10.1007/s11033-011-1413-y
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发表时间：
2011-12
影响因子：
2.8
通讯作者：
Zeng, Hai-Ying
中科院分区：
文献类型：
--
作者：
Xiang, Zuo-Lin;Zeng, Zhao-Chong;Fan, Jia;Tang, Zhao-You;Zeng, Hai-Ying
在本研究中，我们评估了结缔组织生长因子（CTGF）、转化生长因子-β1 （TGF-β1）和白细胞介素-11 （IL-11）在肝细胞癌（HCC）患者根治性切除后瘤内和瘤周表达的预后价值。通过组织微阵列的免疫组化染色，对290例因组织学证实的HCC而行肝切除术的配对肿瘤和瘤周肝组织进行CTGF、TGF-β1和IL-11的表达进行评估。评估这些及其他临床病理因素的预后价值。中位随访时间为54.3个月（范围4.3-118.3个月）。瘤内CTGF高表达与血管侵袭相关（P= 0.015），瘤内IL-11表达与较高的肿瘤淋巴结转移（TNM）分期相关（P= 0.009），瘤周CTGF过表达与肿瘤包封缺失相关（P= 0.031）。相关分析显示，肿瘤内CTGF和IL-11与肿瘤内TGF-β1高表达相关（r= 0.325，P< 0.001; r= 0.273，P< 0.001）。TNM分期（P< 0.001）、瘤内高CTGF水平（P= 0.010）和瘤内IL-11表达（P= 0.015）是无进展生存期（PFS）的独立预后因素。血管浸润（P= 0.032）、TNM分期（P< 0.001）、瘤内高CTGF水平（P= 0.036）、瘤内IL-11表达（P= 0.013）是影响总生存期（OS）的独立预后因素。高肿瘤内CTGF和肿瘤内IL-11表达与肝切除术后PFS和OS相关，肿瘤内CTGF联合IL-11可能预测生存。
In the present study, we evaluated the prognostic value of intratumoral and peritumoral expression of connective tissue growth factor (CTGF), transforming growth factor-beta 1 (TGF-β1), and interleukin-11 (IL-11) in patients with hepatocellular carcinoma (HCC) after curative resection. Expression of CTGF, TGF-β1, and IL-11 was assessed by immunohistochemical staining of tissue microarrays containing paired tumor and peritumoral liver tissue from 290 patients who had undergone hepatectomy for histologically proven HCC. The prognostic value of these and other clinicopathologic factors were evaluated. The median follow-up time was 54.3 months (range, 4.3–118.3 months). High intratumoral CTGF expression was associated with vascular invasion (P= 0.015), intratumoral IL-11 expression correlated with higher tumor node metastasis (TNM) stage (P= 0.009), and peritumoral CTGF overexpression correlated with lack of tumor encapsulation (P= 0.031). Correlation analysis of these proteins revealed that intratumoral CTGF and IL-11 correlated with high intratumoral TGF-β1 expression (r= 0.325,P< 0.001; andr= 0.273,P< 0.001, respectively). TNM stage (P< 0.001), high intratumoral CTGF levels (P= 0.010), and intratumoral IL-11 expression (P= 0.015) were independent prognostic factors for progression-free survival (PFS). Vascular invasion (P= 0.032), TNM stage (P< 0.001), high intratumoral CTGF levels (P= 0.036), and intratumoral IL-11 expression (P= 0.013) were independent prognostic factors for overall survival (OS). High intratumoral CTGF and intratumoral IL-11 expression were associated with PFS and OS after hepatectomy, and the combination of intratumoral CTGF with IL-11 may be predictive of survival.
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影响因子：
5.2
作者：
A. Yoshizaki;T. Nakayama;K. Yamazumi;Y. Yakata;Mitsuru Taba;I. Sekine
通讯作者：
A. Yoshizaki;T. Nakayama;K. Yamazumi;Y. Yakata;Mitsuru Taba;I. Sekine
影响因子：
3.8
作者：
Xiang ZL;Zeng ZC;Tang ZY;Fan J;Zhuang PY;Liang Y;Tan YS;He J
通讯作者：
He J
影响因子：
3.7
作者：
Hanavadi, Satheesha;Martin, Tracey A.;Jiang, Wen G.
通讯作者：
Jiang, Wen G.
影响因子：
45.3
作者：
Poon, RTP;Ng, IOL;Wong, J
通讯作者：
Wong, J
影响因子：
5.8
作者：
Xiang, Zuo-Lin;Zeng, Zhao-Chong;Zhu, Xiao-Dong
通讯作者：
Zhu, Xiao-Dong