Control of arterial pressure by angiotensin II and nitric oxide at the onset of diabetes.
Control of arterial pressure by angiotensin II and nitric oxide at the onset of diabetes.
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糖尿病发作时通过血管紧张素 II 和一氧化氮控制动脉压。
DOI：
10.1016/s0895-7061(03)00902-6
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发表时间：
2003
影响因子：
3.2
通讯作者：
Cloud,LeslieJ
中科院分区：
文献类型：
--
作者：
Brands,MichaelW;Cloud,LeslieJ
We have reported that the induction of diabetes inNω-nitro-L-orginine methyl ester (L-NAME)-infused rats causes significant hypertension that is associated with increased plasma renin activity. This study tested the role of angiotensin II (Ang II) by clamping it chronically at baseline levels. The clamp consisted of an intravenous infusion of enalapril (10 mg/kg/d), which decreased mean arterial pressure (MAP) by ∼20 mm Hg after 3 days, and adding chronic Ang II at 4 ng/kg/min, which restored MAP to normal. Chronic L-NAME infusion increased MAP to 127 ± 1 and 132 ± 2 mm Hg in normal and clamped rats, respectively, and induction of diabetes (streptozotocin) increased MAP progressively in normal rats to 161 ± 8 mm Hg by day 12, whereas MAP in the clamped rats decreased progressively to 98 ± 5 mm Hg by day 12. In non–L-NAME rats, MAP averaged 95 ± 1 and 91 ± 1 mm Hg for normal and clamped groups, respectively, before diabetes, and MAP was 10 to 13 mm Hg lower in the clamped versus normal rats midway through the diabetic period. This suggests that Ang II is important for maintaining blood pressure at the onset of diabetes, possibly to compensate for renal volume losses. Angiotensin II also is required for the hypertension caused by induction of diabetes in rats with chronic blockade of nitric oxide synthesis, but whether this is due to increased volume sensitivity in L-NAME–treated, vasoconstricted rats remains to be determined. Am J Hypertens 2003;16: 600–603 @ 2003 American Journal of Hypertension, Ltd.
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一氧化氮合酶阻断和体液容量。
DOI：
10.1590/s0100-879x2002000100019
发表时间：
2002
期刊：
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
影响因子：
--
作者：
A. Balaszczuk;A. Tomat;S. Bellucci;A. Fellet;C. Arranz
通讯作者：
C. Arranz
糖尿病患者的肾灌注和肾脏血流动力学对阻断肾素系统的反应：导致血管舒张和血管收缩的力量是否相关？
影响因子：
7.7
作者：
M. Lansang;N. Hollenberg
通讯作者：
N. Hollenberg
影响因子：
8.3
作者：
Brands, MW;Fitzgerald, SM
通讯作者：
Fitzgerald, SM
一氧化氮合成的抑制会在大鼠慢性输注葡萄糖期间加剧高血压。
DOI：
10.1161/01.hyp.35.1.451
发表时间：
2000
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Claxton,CR;Brands,MW;Fitzgerald,SM;Cameron,JA
通讯作者：
Cameron,JA
高血糖中肾血流动力学的控制：肾小球反馈的可能作用。
DOI：
10.1152/ajprenal.1987.252.1.f65
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Woods,LL;Mizelle,HL;Hall,JE
通讯作者：
Hall,JE