Antimicrobial photodynamic therapy for methicillin-resistant Staphylococcus aureus infection.

Antimicrobial photodynamic therapy for methicillin-resistant Staphylococcus aureus infection.
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DOI:
10.1155/2013/159157
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发表时间:
2013
影响因子:
--
通讯作者:
Yao M
Yao M
中科院分区:
生物学3区
文献类型:
--
作者:
Fu XJ;Fang Y;Yao M

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如今,耐甲氧西林金黄色葡萄球菌(MRSA)是医院和社区中最常见的多重耐药细菌之一。在过去的二十年里,人们越来越担心最有效的抗生素糖肽对 MRSA 的耐药性不断增强。 MRSA 感染给医生及其患者带来了严重的问题。光敏剂介导的抗菌光动力疗法(PDT)似乎是治疗多重耐药感染的一种有前途且创新的方法。尽管在大型体外研究中使用抗菌 PDT 灭活 MRSA 的报道令人鼓舞,但体内研究却很少。因此,将PDT应用于临床治疗MRSA感染还有很长的路要走。
Nowadays methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug resistant bacteria both in hospitals and in the community. In the last two decades, there has been growing concern about the increasing resistance to MRSA of the most potent antibiotic glycopeptides. MRSA infection poses a serious problem for physicians and their patients. Photosensitizer-mediated antimicrobial photodynamic therapy (PDT) appears to be a promising and innovative approach for treating multidrug resistant infection. In spite of encouraging reports of the use of antimicrobial PDT to inactivate MRSA in large in vitro studies, there are only few in vivo studies. Therefore, applying PDT in the clinic for MRSA infection is still a long way off.
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