A population-based, longitudinal study of erectile dysfunction and future coronary artery disease.
A population-based, longitudinal study of erectile dysfunction and future coronary artery disease.
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DOI：
10.4065/84.2.108
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发表时间：
2009-02
影响因子：
8.9
通讯作者：
Jacobsen SJ
中科院分区：
文献类型：
--
作者：
Inman BA;Sauver JL;Jacobson DJ;McGree ME;Nehra A;Lieber MM;Roger VL;Jacobsen SJ
评估勃起功能障碍（艾德）与冠状动脉疾病（CAD）长期风险之间的关系，以及年龄作为该关系的修正因素的作用。从1996年1月1日至2005年12月31日，我们每两年随机抽取1402名有固定性伴侣且无已知CAD的社区居住男性，筛查ED的存在。年龄分层后计算CAD的发病率密度，并通过时间依赖性考克斯比例风险模型校正潜在混杂因素。40 - 49岁男性的艾德患病率为2%，50 - 59岁男性为6%，60 - 69岁男性为17%，70岁或以上男性为39%。各年龄组中无艾德男性的CAD发病密度/1000人-年分别为0.94（40-49岁）、5.09（50-59岁）、10.72（60-69岁）和23.30（≥70岁）。对于男性艾德，各年龄组的CAD发病密度分别为48.52（40-49岁）、27.15（50-59岁）、23.97（60-69岁）和29.63（≥70岁）。艾德和CAD可能是共同的潜在血管病理学的不同表现。当艾德发生在年轻男性时，它与未来心脏事件风险的显著增加相关，而在老年男性中，艾德似乎没有什么预后意义。年轻男性艾德可能是心血管危险因素筛查和医疗干预的理想人选。
To assess the association between erectile dysfunction (ED) and the long-term risk of coronary artery disease (CAD) and the role of age as a modifier of this association. From January 1, 1996, to December 31, 2005, we biennially screened a random sample of 1402 community-dwelling men with regular sexual partners and without known CAD for the presence of ED. Incidence densities of CAD were calculated after age stratification and adjusted for potential confounders by time-dependent Cox proportional hazards models. The prevalence of ED was 2% for men aged 40 to 49 years, 6% for men aged 50 to 59 years, 17% for men aged 60 to 69 years, and 39% for men aged 70 years or older. The CAD incidence densities per 1000 person-years for men without ED in each age group were 0.94 (40-49 years), 5.09 (50-59 years), 10.72 (60-69 years), and 23.30 (≥70 years). For men with ED, the incidence densities of CAD for each age group were 48.52 (40-49 years), 27.15 (50-59 years), 23.97 (60-69 years), and 29.63 (≥70 years). ED and CAD may be differing manifestations of a common underlying vascular pathology. When ED occurs in a younger man, it is associated with a marked increase in the risk of future cardiac events, whereas in older men, ED appears to be of little prognostic importance. Young men with ED may be ideal candidates for cardiovascular risk factor screening and medical intervention.
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影响因子：
6.6
作者：
Kupelian, Varant;Shabsigh, Ridwan;McKinlay, John B.
通讯作者：
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