Impaired prefrontal activity to regulate the intrinsic motivation-action link in schizophrenia.
Impaired prefrontal activity to regulate the intrinsic motivation-action link in schizophrenia.
复制标题
DOI：
10.1016/j.nicl.2017.07.003
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Nakagome K
中科院分区：
文献类型：
--
作者：
Takeda K;Matsumoto M;Ogata Y;Maida K;Murakami H;Murayama K;Shimoji K;Hanakawa T;Matsumoto K;Nakagome K
精神分裂症(SCZ)的一个核心特征是内在动机障碍。尽管内在动机在促进社会功能改善方面起着重要作用，但其损伤的神经机制尚不清楚。我们推测由纹状体和外侧前额叶皮质(LPFC)组成的额纹状体环的功能异常可能与SCZ的内在动机受损有关。我们通过比较18名稳定的SCZ患者和17名健康对照(HC)参与者在一项引发内在动机的任务中测量的大脑活动和与运动、动机和认知控制相关的行为参数来测试这一点。我们还利用扩散张量成像分析比较了两组患者在静息状态下的功能连通性和分数各向异性。我们采用了一个令人愉快的计时任务来在准确的时间停止秒表，这在我们之前的研究中已经证明可以激发内在动机。尽管总体表现水平在不同组之间没有差别，但在发生“超调”错误(即反应太晚)后的试验中，SCZ组的表现比HC组差。在一份清单报告中，SCZ参与者对这项任务的内在动机低于HC组。在任务提示期的预测中，SCZ参与者的纹状体活动始终低于HC参与者。在HC组，LPFC活动在任务线索阶段与内在动机呈正相关，与超调错误的成功率呈正相关，而在SCZ组，LPFC活性与内在动机呈正相关。两组在任务提示时的LPFC活性也与纹状体活动呈正相关。反馈期间的纹状体活动在组间无显著差异。这些结果表明，与HC不同，LPFC中的神经活动未能在SCZ中对享乐事件的预测和对行动计划的认知控制之间起到中介作用，而享乐反应被保留下来。用功能磁共振成像技术研究了精神分裂症动机受损的神经基础。精神分裂症患者对纹状体反馈的享乐反应仍然存在。认知控制能力差阻碍了将享乐主义事件转化为行动计划。认知控制障碍与前额叶功能改变有关。
A core feature of schizophrenia (SCZ) is impairment in intrinsic motivation. Although intrinsic motivation plays an important role in enhancing improvement of the social functioning, its neural mechanisms of impairment have yet to be clarified. We hypothesized that abnormal function of the frontostriatal loop consisting of the striatum and lateral prefrontal cortex (LPFC) may be related to impaired intrinsic motivation in SCZ. We tested this by comparing the brain activity measured by functional magnetic resonance imaging and behavioral parameters associated with movement, motivation, and cognitive control between 18 stable SCZ patients and 17 healthy control (HC) participants during a task that elicits intrinsic motivation. We also compared the functional connectivity during resting-state and the fractional anisotropy using diffusion tensor imaging analysis between the two groups. We adopted an enjoyable timing task to stop a stopwatch at an exact time, which in our previous study has demonstrated to elicit intrinsic motivation. Although the performance level in general was not different between groups, the SCZ group performed worse than the HC group in trials following “overshoot” errors (i.e., the response was too late). SCZ participants showed lower intrinsic motivation to the task than the HC group in an inventory report. The striatal activity during the prediction at the task cue period was consistently lower in SCZ participants than in HC. The LPFC activity at the task cue period positively correlated with intrinsic motivation and also with the rate of success following overshoot errors in the HC group, but not in the SCZ group. The LPFC activity at the task cue period was also positively correlated with the striatal activity in both groups. The striatal activity during the feedback period was not significantly different between groups. These results suggest that, unlike HC, the neural activity in the LPFC fails to mediate between prediction of hedonic events and cognitive control of action plans in SCZ, whereas the hedonic response is retained. The neural basis of impaired motivation in schizophrenia is examined using fMRI. The hedonic response to a feedback in the striatum is retained in schizophrenia. Translating hedonic events to action plans is impeded by poor cognitive control. The cognitive control impairment is associated with altered prefrontal function.
登录
查看更多内容
影响因子：
4.5
作者：
Gard, David E.;Fisher, Melissa;Vinogradov, Sophia
通讯作者：
Vinogradov, Sophia
影响因子：
4.6
作者：
Heerey, Erin A.;Gold, James M.
通讯作者：
Gold, James M.
影响因子：
3.4
作者：
Juckel, Georg;Schlagenhauf, Florian;Heinz, Andreas
通讯作者：
Heinz, Andreas
影响因子：
5.7
作者：
Deichmann, R;Gottfried, JA;Turner, R
通讯作者：
Turner, R
影响因子：
6.6
作者：
Green, MF;Kern, RS;Mintz, J
通讯作者：
Mintz, J