Leisure-time running reduces all-cause and cardiovascular mortality risk.
Leisure-time running reduces all-cause and cardiovascular mortality risk.
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DOI：
10.1016/j.jacc.2014.04.058
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发表时间：
2014-08-05
影响因子：
24
通讯作者：
Blair, Steven N.
中科院分区：
文献类型：
--
作者：
Lee, Duck-chul;Pate, Russell R.;Lavie, Carl J.;Sui, Xuemei;Church, Timothy S.;Blair, Steven N.
关键词：
虽然跑步是一种流行的休闲体育活动，但人们对跑步对死亡率的长期影响知之甚少。跑步之间的剂量反应关系，以及跑步行为随时间的变化和死亡率仍然不确定。我们研究了55,137名年龄在18至100岁（平均年龄44岁）的成年人跑步与全因和心血管死亡风险的关系。通过病史调查问卷对跑步进行评估。在平均15年的随访期间，发生了3，413例全因死亡和1，217例心血管死亡。大约有24%的成年人参加了这一人群的跑步。与非跑步者相比，跑步者的全因死亡率和心血管死亡率分别降低了30%和45%，预期寿命延长了3年。在剂量反应分析中，跑步者的死亡率效益在跑步时间、距离、频率、数量和速度的五分位数上与非跑步者相似。与不跑步相比，即使每周跑步<51分钟，<6英里，1-2次，<506代谢当量分钟，或<6英里/小时，也足以降低死亡风险。在对跑步行为和死亡率变化的分析中，与从不跑步者相比，坚持跑步者的全因和心血管死亡率分别降低了29%和50%。跑步，即使是每天5-10分钟，慢速<6英里/小时，也与所有原因和心血管疾病的死亡风险显着降低有关。这项研究可能会激励健康但久坐的个体开始并继续跑步，以获得实质性和可达到的死亡率益处。
Although running is a popular leisure-time physical activity, little is known about the long-term effects of running on mortality. The dose-response relations between running, as well as the change in running behaviors over time and mortality remain uncertain. We examined the associations of running with all-cause and cardiovascular mortality risks in 55,137 adults, aged 18 to 100 years (mean age, 44). Running was assessed on the medical history questionnaire by leisure-time activity. During a mean follow-up of 15 years, 3,413 all-cause and 1,217 cardiovascular deaths occurred. Approximately, 24% of adults participated in running in this population. Compared with non-runners, runners had 30% and 45% lower adjusted risks of all-cause and cardiovascular mortality, respectively, with a 3-year life expectancy benefit. In dose-response analyses, the mortality benefits in runners were similar across quintiles of running time, distance, frequency, amount, and speed, compared with non-runners. Weekly running even <51 minutes, <6 miles, 1-2 times, <506 metabolic equivalent-minutes, or <6 mph was sufficient to reduce risk of mortality, compared with not running. In the analyses of change in running behaviors and mortality, persistent runners had the most significant benefits with 29% and 50% lower risks of all-cause and cardiovascular mortality, respectively, compared with never-runners. Running, even 5-10 minutes per day and slow speeds <6 mph, is associated with markedly reduced risks of death from all causes and cardiovascular disease. This study may motivate healthy but sedentary individuals to begin and continue running for substantial and attainable mortality benefits.
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