White matter integrity and cortical metabolic associations in aging and dementia.
White matter integrity and cortical metabolic associations in aging and dementia.
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DOI：
10.1016/j.jalz.2009.04.1228
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Jagust W
中科院分区：
文献类型：
--
作者：
Kuczynski B;Targan E;Madison C;Weiner M;Zhang Y;Reed B;Chui HC;Jagust W
研究表明，白色物质高信号，无论位置如何，主要影响额叶代谢和功能。本报告调查如何区域白色物质的完整性（测量分数各向异性（FA））与脑代谢，以解开白色物质的变化和脑代谢之间的复杂关系。在16例正常至痴呆（年龄>55岁）受试者队列中，使用扩散张量成像（DTI）和氟脱氧葡萄糖-正电子发射断层扫描（FDG-PET）阐明白色物质完整性与灰质代谢之间的关系。采用SPM 2（p < 0.005，体素簇> 100）对内侧前额叶、前外侧前额叶、顶叶联合区和后颞区以及胼胝体下方的白色白质区域的平均FA值进行横断面回归分析，并对葡萄糖代谢（PET）进行回归。局部脑葡萄糖代谢是主要的结果指标，我们的主要假设是那些受阿尔茨海默病影响的低代谢皮质区与相关轨道的FA降低相关。我们的数据显示，区域间的正相关FA和灰质代谢的前额叶皮层，颞叶和顶叶区域。我们的研究结果表明，左前额叶FA与左颞顶叶代谢。此外，左后颞FA与左前额叶代谢相关。最后，双侧顶叶FA与双侧颞叶代谢相关。这些区域与AD和脑血管疾病中受影响的认知过程相关，表明与白色物质变性和灰质代谢减退有关。因此，皮质功能和白色物质退化在老化和痴呆中是相关的。
Studies show white matter hyperintensities, regardless of location, primarily affect frontal lobe metabolism and function. This report investigates how regional white matter integrity (measured as fractional anisotropy (FA)) relates to brain metabolism in order to unravel the complex relationship between white matter change and brain metabolism. To elucidate the relationship between white matter integrity and gray matter metabolism using diffusion tensor imaging (DTI) and fluorodeoxyglucose-positron emission tomography (FDG-PET) in a cohort of 16 subjects ranging from normal to demented (age>55). Cross-sectional regression analyses using mean FA values from white matter regions underlying the medial prefrontal, inferior-lateral prefrontal, parietal association, and posterior temporal areas and corpus callosum were regressed with glucose metabolism (PET) using SPM2 (p < 0.005, voxel cluster > 100). Regional cerebral glucose metabolism was the primary outcome measure, with our major hypotheses being those hypometabolic cortical regions affected by Alzheimer’s disease would correlate with lower FA of associated tracks. Our data show inter-regional positive correlations between FA and gray matter metabolism for the prefrontal cortex, temporal and parietal regions. Our results suggest left prefrontal FA is associated with left temporal and parietal metabolism. Further, left posterior temporal FA correlated with left prefrontal metabolism. Finally, bilateral parietal FA correlated with bilateral temporal metabolism. These regions are associated with the cognitive processes affected in AD and Cerebrovascular Disease, suggesting a link with white matter degeneration and gray matter hypometabolism. Therefore cortical function and white matter degeneration are related in aging and dementia.
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