Periconceptional biomarkers for maternal obesity: a systematic review.
Periconceptional biomarkers for maternal obesity: a systematic review.
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DOI：
10.1007/s11154-022-09762-5
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发表时间：
2023-04
影响因子：
8.2
通讯作者：
Schoenmakers, Sam
中科院分区：
文献类型：
--
作者：
Hojeij, Batoul;Rousian, Melek;Sinclair, Kevin D.;Dinnyes, Andras;Steegers-Theunissen, Regine P. M.;Schoenmakers, Sam
围孕产妇肥胖与不良的孕产妇和新生儿结局有关。识别受孕产妇肥胖影响的围孕生物标志物可以揭示病理生理机制并识别面临不良临床结果风险的个体。系统地回顾了文献，以确定受孕产妇肥胖影响的内分泌、炎症和一碳代谢途径的围孕生物标志物。在 Embase、Ovid Medline All、Web of Science Core Collection 和 Cochrane Central Register of Controlled Trials 数据库中进行检索，并在 PubMed 中进行手动检索，直至 2020 年 12 月 31 日。符合条件的研究是在围孕期（孕前 14 周至孕后 14 周）测量与孕产妇肥胖、超重/肥胖或体重指数 (BMI) 相关的生物标志物的研究构想）。 ErasmusAGE 评分用于评估纳入研究的质量。纳入的 51 篇文章评估了 40 多种生物标志物。与孕产妇肥胖相关的内分泌生物标志物包括瘦素、胰岛素、促甲状腺激素、脂联素、黄体酮、游离 T4 和人绒毛膜促性腺激素。 C 反应蛋白作为炎症途径的一部分与肥胖相关，而相关的一碳代谢生物标志物是叶酸和维生素 B12。 BMI与瘦素、C反应蛋白和胰岛素抵抗呈正相关，与游离T4、黄体酮和人绒毛膜促性腺激素呈负相关。关于其余研究的生物标志物，由于数据有限或相互矛盾，无法得出强有力的结论。未来的研究应侧重于确定最佳生物标志物组在临床环境中使用的预测价值。最有前途的生物标志物包括瘦素、脂联素、人绒毛膜促性腺激素、胰岛素、黄体酮和 CRP。在线版本包含可在 10.1007/s11154-022-09762-5 获取的补充材料。
Periconceptional maternal obesity is linked to adverse maternal and neonatal outcomes. Identifying periconceptional biomarkers of pathways affected by maternal obesity can unravel pathophysiologic mechanisms and identify individuals at risk of adverse clinical outcomes. The literature was systematically reviewed to identify periconceptional biomarkers of the endocrine, inflammatory and one-carbon metabolic pathways influenced by maternal obesity. A search was conducted in Embase, Ovid Medline All, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases, complemented by manual search in PubMed until December 31st, 2020. Eligible studies were those that measured biomarker(s) in relation to maternal obesity, overweight/obesity or body mass index (BMI) during the periconceptional period (14 weeks preconception until 14 weeks post conception). The ErasmusAGE score was used to assess the quality of included studies. Fifty-one articles were included that evaluated over 40 biomarkers. Endocrine biomarkers associated with maternal obesity included leptin, insulin, thyroid stimulating hormone, adiponectin, progesterone, free T4 and human chorionic gonadotropin. C-reactive protein was associated with obesity as part of the inflammatory pathway, while the associated one-carbon metabolism biomarkers were folate and vitamin B12. BMI was positively associated with leptin, C-reactive protein and insulin resistance, and negatively associated with Free T4, progesterone and human chorionic gonadotropin. Concerning the remaining studied biomarkers, strong conclusions could not be established due to limited or contradictory data. Future research should focus on determining the predictive value of the optimal set of biomarkers for their use in clinical settings. The most promising biomarkers include leptin, adiponectin, human chorionic gonadotropin, insulin, progesterone and CRP. The online version contains supplementary material available at 10.1007/s11154-022-09762-5.
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DOI：
10.1080/09513590.2017.1393511
发表时间：
2018-04
期刊：
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
影响因子：
--
作者：
Al-Safi ZA;Polotsky A;Chosich J;Roth L;Allshouse AA;Bradford AP;Santoro N
通讯作者：
Santoro N
影响因子：
7.2
作者：
Borissova, AM;Tankova, TI;Koev, DJ
通讯作者：
Koev, DJ
影响因子：
3.1
作者：
Brady, Paula C.;Kaser, Daniel J.;Racowsky, Catherine
通讯作者：
Racowsky, Catherine
影响因子：
9.8
作者：
Bernasconi, D;DelMonte, P;Marugo, M
通讯作者：
Marugo, M
影响因子：
5.8
作者：
Adaikalakoteswari, Antonysunil;Vatish, Manu;Saravanan, Ponnusamy
通讯作者：
Saravanan, Ponnusamy