Evidence for disruption of normal circadian cortisol rhythm in women with obesity.
Evidence for disruption of normal circadian cortisol rhythm in women with obesity.
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DOI：
10.1080/09513590.2017.1393511
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Santoro N
中科院分区：
文献类型：
--
作者：
Al-Safi ZA;Polotsky A;Chosich J;Roth L;Allshouse AA;Bradford AP;Santoro N
下丘脑-垂体-肾上腺（HPA）轴的过度活跃可能在肥胖合并症的发病机制中起作用，包括我们和其他人观察到的相对低促性腺激素性腺功能减退症。我们试图在正常体重的妇女和肥胖妇女的样本中检查白天和晚上的血清皮质醇谱。在这项横断面研究中，招募了经常骑自行车的肥胖（n=12）和正常体重（n=10）女性。在月经周期的黄体期，通过16小时（上午8点至午夜）频繁采血测定平均血清皮质醇。与正常体重的女性相比，肥胖女性的总体皮质醇水平显著更高（6.2 [4.3，6.6] vs 4.7 [3.7，5.5] ug/dl，p=0.04）。在餐后两小时内，肥胖女性的皮质醇水平（7.2 [6.5，8.6] ug/dl）几乎是正常体重对照组（4.4 [3.7，6.2] ug/dl，p<0.01）的两倍。此外，与正常体重的女性相比，肥胖女性表现出持续的夜间皮质醇升高，正常体重的女性表现出典型的皮质醇下降（3.2 [2.3，4] vs 2 [1.5，3.2] ug/dl，p<0.05）。肥胖患者HPA轴的改变可能与肥胖相关的代谢合并症和生殖功能障碍的风险有关。
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis may play a role in the pathogenesis of comorbidities encountered in obesity, including the relative hypogonadotropic hypogonadism that we and others have observed. We sought to examine serum cortisol profiles throughout the day and evening in a sample of normal weight women and women with obesity. In this cross-sectional study, regularly cycling obese (n=12) and normal weight (n=10) women were recruited. Mean serum cortisol was measured by frequent blood sampling for 16 hours (8am-midnight) in the luteal phase of the menstrual cycle. Women with obesity had significantly higher overall cortisol levels when compared to normal weight women (6.2 [4.3, 6.6] vs 4.7 [3.7, 5.5] ug/dl, p=0.04). Over the two-hour post-prandial period, obese women displayed an almost two-fold greater (7.2 [6.5, 8.6] ug/dl) rise in cortisol than normal weight controls (4.4 [3.7, 6.2] ug/dl, p<0.01). In addition, obese women demonstrated a sustained evening cortisol elevation compared to normal weight women, who displayed the typical decline in cortisol (3.2 [2.3, 4] vs 2 [1.5, 3.2] ug/dl, p<0.05). Changes in the HPA axis in the setting of obesity may be related to risks of obesity-associated metabolic comorbidities and reproductive dysfunction often seen in these women.
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影响因子：
6.9
作者：
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5.8
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