Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding.
Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding.
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DOI：
10.1002/jeab.754
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发表时间：
2022-05
影响因子：
2.7
通讯作者：
Salamone, John D.
中科院分区：
文献类型：
--
作者：
Ren, Naxin;Carratala-Ros, Carla;Ecevitoglu, Alev;Rotolo, Renee A.;Edelstein, Gayle A.;Presby, Rose E.;Stevenson, Ian H.;Chrobak, James J.;Salamone, John D.
多巴胺消耗剂丁苯那嗪改变了基于努力的选择，抑制了具有高反应要求的食物强化行为，同时增加了低成本选择的选择。在本实验中，对大鼠进行了并行固定比率5/食物喂养选择任务的测试，其中高碳水化合物Bio-serv颗粒增强了杠杆按压，并且实验室食物同时可用。用事件记录系统监测杠杆按压的详细时间，并分析1.0 mg/kg丁苯那嗪或溶媒注射后观察到的操作行为的时间特征。丁苯那嗪改变了选择，减少了杠杆压力，但增加了食物摄入量。对比率内的反应时间分布有很小的影响，但反应暂停的总持续时间显着增加。加强后暂停（PRP）的分布是双峰，但丁苯那嗪没有增加的时间PRP。丁苯那嗪增加时间喂养和持续时间和喂养回合数，但不影响喂养率或总时间花杠杆压颗粒和消费的食物。因此，TBZ似乎主要影响杠杆按压与食物的相对分配，在涉及食物摄入的完成运动行为中几乎没有改变。丁苯那嗪被用来模拟精神病理学中的动机症状，这些对大鼠的影响可能对精神病学研究有影响。
The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, rats were tested on a concurrent fixed ratio 5/chow feeding choice task, in which high-carbohydrate Bio-serv pellets reinforced lever pressing and lab chow was concurrently available. Detailed timing of lever pressing was monitored with an event recording system, and the temporal characteristics of operant behavior seen after 1.0 mg/kg tetrabenazine or vehicle injections were analyzed. Tetrabenazine shifted choice, decreasing lever pressing but increasing chow intake. There was a small effect on the interresponse-time distribution within ratios, but marked increases in the total duration of pauses in responding. The postreinforcement-pause (PRP) distribution was bimodal, but tetrabenazine did not increase the duration of PRPs. Tetrabenazine increased time feeding and duration and number of feeding bouts, but did not affect feeding rate or total time spent lever pressing for pellets and consuming chow. Thus, TBZ appears to predominantly affect the relative allocation of lever pressing versus chow, with little alteration in consummatory motor acts involved in chow intake. Tetrabenazine is used to model motivational symptoms in psychopathology, and these effects in rats could have implications for psychiatric research.
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