Therapeutic Potential of Niche-Specific Mesenchymal Stromal Cells for Spinal Cord Injury Repair.
Therapeutic Potential of Niche-Specific Mesenchymal Stromal Cells for Spinal Cord Injury Repair.
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DOI：
10.3390/cells10040901
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发表时间：
2021-04-14
期刊：
影响因子：
6
通讯作者：
Barnett SC
中科院分区：
文献类型：
--
作者：
Lindsay SL;Barnett SC
骨髓间充质干/基质细胞（MSCs）移植介导的修复脊髓损伤（SCI）后的一个重要的和有前途的治疗策略。间充质干细胞的吸引力是由于其易于分离，免疫抑制特性和低免疫原性，以及各种各样的可用组织来源。然而，尽管报道了体外相似性，但来源于不同组织的MSC在体内可能不具有可比的生物学特性。越来越多的证据表明，干细胞的干性、可塑性、免疫原性和适应性在很大程度上受组织生态位的控制。因此，细胞小生境对MSC修复潜力的外在影响是重要的，尤其是因为其对用于治疗目的的离体扩增的影响。可能某些利基靶向的MSC更适合SCI移植介导的修复，因为它们的内在能力，例如固有的神经原性。此外，MSC解剖位置的不同意味着收获和培养程序的差异可能会使临床前数据的交叉比较变得困难。由于临床级MSC产品与其制造密不可分，因此必须使用适当的材料相对容易地制造细胞。我们讨论了这些问题，并强调了确定适当的利基特异性MSC类型的SCI修复的重要性。
The use of mesenchymal stem/stromal cells (MSCs) for transplant-mediated repair represents an important and promising therapeutic strategy after spinal cord injury (SCI). The appeal of MSCs has been fuelled by their ease of isolation, immunosuppressive properties, and low immunogenicity, alongside the large variety of available tissue sources. However, despite reported similarities in vitro, MSCs sourced from distinct tissues may not have comparable biological properties in vivo. There is accumulating evidence that stemness, plasticity, immunogenicity, and adaptability of stem cells is largely controlled by tissue niche. The extrinsic impact of cellular niche for MSC repair potential is therefore important, not least because of its impact on ex vivo expansion for therapeutic purposes. It is likely certain niche-targeted MSCs are more suited for SCI transplant-mediated repair due to their intrinsic capabilities, such as inherent neurogenic properties. In addition, the various MSC anatomical locations means that differences in harvest and culture procedures can make cross-comparison of pre-clinical data difficult. Since a clinical grade MSC product is inextricably linked with its manufacture, it is imperative that cells can be made relatively easily using appropriate materials. We discuss these issues and highlight the importance of identifying the appropriate niche-specific MSC type for SCI repair.
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