Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia.
Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia.
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DOI：
10.1038/s41419-022-05114-y
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发表时间：
2022-08-01
影响因子：
9
通讯作者：
Liu, Xiaodong
中科院分区：
文献类型：
--
作者：
Jiao, Benzheng;Liu, Shanshan;Zhao, Hongguang;Zhuang, Yuying;Ma, Shumei;Lin, Chenghe;Hu, Jifan;Liu, Xiaodong
鉴于RNA-seq技术和生物信息学分析的快速发展，环状RNA（circRNA）逐渐被认为是一类新型的内源性RNA，其特征是缺乏自由末端的共价环结构，在癌症发生、发展和转移中发挥多种生物学功能。缺氧是肿瘤微环境的一个共同特征，通过调节编码和非编码转录组，深刻影响肿瘤细胞的几种基本适应性反应，并使癌症的表型更具侵袭性。最近，缺氧响应性circRNA被认为是缺氧诱导的非编码RNA转录组学中的新参与者，可调节缺氧反应并促进缺氧肿瘤的进展和转移。此外，通过细胞外囊泡-外泌体，这些缺氧反应性circRNA可以将癌细胞的缺氧反应传递到周围基质的细胞，甚至是其他器官的更远的细胞。在这里，我们总结了关于缺氧反应性circRNA的已知信息，重点关注它们与缺氧诱导因子（HIF）的相互作用、缺氧反应的调节以及与恶性肿瘤临床特征的相关性，这将为非编码RNA在缺氧应激下对癌细胞的调节提供新的见解，并可能有助于识别新的治疗靶点，并为那些对放化疗产生耐药性的癌症患者定义新的治疗策略。肿瘤缺氧。
Given the rapid developments in RNA-seq technologies and bioinformatic analyses, circular RNAs (circRNAs) have gradually become recognized as a novel class of endogenous RNAs, characterized by covalent loop structures lacking free terminals, which perform multiple biological functions in cancer genesis, progression and metastasis. Hypoxia, a common feature of the tumor microenvironments, profoundly affects several fundamental adaptive responses of tumor cells by regulating the coding and non-coding transcriptomes and renders cancer’s phenotypes more aggressive. Recently, hypoxia-responsive circRNAs have been recognized as a novel player in hypoxia-induced non-coding RNA transcriptomics to modulate the hypoxic responses and promote the progression and metastasis of hypoxic tumors. Moreover, via extracellular vesicles-exosomes, these hypoxia-responsive circRNAs could transmit hypoxia responses from cancer cells to the cells of surrounding matrices, even more distant cells of other organs. Here, we have summarized what is known about hypoxia-responsive circRNAs, with a focus on their interaction with hypoxia-inducible factors (HIFs), regulation of hypoxic responses and relevance with malignant carcinoma’s clinical features, which will offer novel insights on the non-coding RNAs’ regulation of cancer cells under hypoxic stress and might aid the identification of new theranostic targets and define new therapeutic strategies for those cancer patients with resistance to radiochemotherapy, because of the ubiquity of tumoral hypoxia.
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影响因子：
5.6
作者：
Barreca MM;Zichittella C;Alessandro R;Conigliaro A
通讯作者：
Conigliaro A
环状RNA circ-ERBIN通过miR-125a-5p和miR-138-5p/4EBP-1介导的不依赖帽的HIF-1 α翻译促进结直肠癌的生长和转移
影响因子：
37.3
作者：
Chen LY;Wang L;Ren YX;Pang Z;Liu Y;Sun XD;Tu J;Zhi Z;Qin Y;Sun LN;Li JM
通讯作者：
Li JM
影响因子：
4.7
作者：
Jin, Yue;Che, Xiaofang;Liu, Yunpeng
通讯作者：
Liu, Yunpeng
DOI：
10.1186/s13046-021-01926-6
发表时间：
2021-05-08
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
D'Aguanno S;Mallone F;Marenco M;Del Bufalo D;Moramarco A
通讯作者：
Moramarco A
影响因子：
4
作者：
Chi, Yongbing;Luo, Qiancheng;Zhang, Denghai
通讯作者：
Zhang, Denghai