Conditioned enhancement of the nicotine reinforcer.
Conditioned enhancement of the nicotine reinforcer.
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DOI：
10.1037/pha0000370
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发表时间：
2021-08
影响因子：
2.3
通讯作者：
Bevins RA
中科院分区：
文献类型：
--
作者：
Charntikov S;Pittenger ST;Swalve N;Barrett ST;Bevins RA
这项研究旨在评估尼古丁是否可以通过与其他奖励的关联获得额外的强化特性。为此，在调节阶段，大鼠自行服用尼古丁（0.01 mg/kg）或尼古丁与蔗糖配对。在随后的挑战阶段，我们测试了尼古丁-蔗糖配对对尼古丁强化效应的影响，使用渐进比例强化计划。使用这种方法，我们发现：(a)在研究的初始条件阶段，成对和单独尼古丁条件下的大鼠在每次摄入限制为10次时，自我施用相似量的尼古丁；(b)在成对条件下，尼古丁迅速获得了对目标跟踪行为的控制；(c)有尼古丁和蔗糖配对历史的大鼠工作更努力，并且使用不同的反应形式以进步比例测量更多的尼古丁。(d)在尼古丁自我给药的11天时间里，当蔗糖不再与尼古丁配对时，尼古丁诱发的条件目标跟踪并没有消失。总的来说，我们的研究结果表明，除了尼古丁刺激的多面性，包括初级强化效应、条件强化效应和奖励增强效应外，尼古丁还可以通过与其他奖励的关联获得额外的强化特性。这种通过联想学习获得额外强化特性的能力可能有助于烟草使用障碍的发展和长期存在。
This study was designed to assess whether nicotine can acquire additional reinforcing properties through associations with other rewards. To this end, rats self-administered nicotine-alone (0.01 mg/kg) or nicotine paired with access to sucrose during the conditioning phase. In the subsequent challenge phase, we tested the effect of nicotine-sucrose pairings on the reinforcing effects of nicotine using a progressive ratio schedule of reinforcement. Using this approach, we show that (a) rats in both paired and nicotine-alone conditions self-administered similar amounts of nicotine in the initial conditioning phase of the study when intake was limited to 10 infusions per session, (b) nicotine rapidly acquired control over goal-tracking behavior in the paired condition, (c) rats that had a history of nicotine and sucrose pairings worked harder and took more nicotine as measured on a progressive ratio using a distinct response form, and (d) conditioned goal-tracking evoked by nicotine did not show extinction when sucrose was no longer paired with nicotine over the 11 days of nicotine self-administration on a progressive ratio schedule of reinforcement. Overall, our results demonstrate that in addition to the multifaceted nature of nicotine stimulus that includes primary reinforcing effects, conditioned reinforcing effects, and reward enhancing effects, nicotine can also acquire additional reinforcing properties through associations with other rewards. This ability to acquire additional reinforcing properties through associative learning may contribute to the development and perpetuation of tobacco use disorder.
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影响因子：
3.4
作者：
Chaudhri, Nadia;Caggiula, Anthony R.;Sved, Alan F.
通讯作者：
Sved, Alan F.
影响因子：
4.2
作者：
Charntikov, Sergios;Pittenger, Steven T.;Pendyala, Gurudutt
通讯作者：
Pendyala, Gurudutt
影响因子：
3.4
作者：
CORRIGALL, WA;COEN, KM
通讯作者：
COEN, KM
影响因子：
2.3
作者：
Alessi, SM;Roll, JM;Johanson, CE
通讯作者：
Johanson, CE
影响因子：
1.4
作者：
Cahill, Kate;Stead, Lindsay F.;Polonio, Igor Bastos
通讯作者：
Polonio, Igor Bastos