Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations.
Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations.
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DOI：
10.3390/pharmaceutics12121171
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发表时间：
2020-12-01
期刊：
影响因子：
5.4
通讯作者：
Batrakova EV
中科院分区：
文献类型：
--
作者：
Klyachko NL;Arzt CJ;Li SM;Gololobova OA;Batrakova EV
药物纳米制剂对于有效地将治疗药物输送到疾病部位具有显著的前景。不幸的是，人工纳米载体，主要是脂质体和聚合物纳米颗粒，由于不利的药代动力学和网状内皮系统（RES）快速从血液循环中清除，其应用有限。此外，它们中的许多具有高细胞毒性，低生物降解性，并且无法跨越生物屏障，包括血脑屏障。细胞外囊泡（EVs）是一种具有高生物利用度、特殊生物相容性和低免疫原性的新型药物递送系统。它们为细胞间通信和生物活性化合物向目标组织、细胞和器官的传递提供了一种手段。这些特点使得它们近年来作为一种治疗平台越来越有吸引力。然而，设计基于ev的治疗方法存在许多障碍。在这篇综述中，我们将概述载药EV制剂治疗和临床应用的主要障碍和限制，并描述解决这些问题的各种尝试。
Drug nanoformulations hold remarkable promise for the efficient delivery of therapeutics to a disease site. Unfortunately, artificial nanocarriers, mostly liposomes and polymeric nanoparticles, show limited applications due to the unfavorable pharmacokinetics and rapid clearance from the blood circulation by the reticuloendothelial system (RES). Besides, many of them have high cytotoxicity, low biodegradability, and the inability to cross biological barriers, including the blood brain barrier. Extracellular vesicles (EVs) are novel candidates for drug delivery systems with high bioavailability, exceptional biocompatibility, and low immunogenicity. They provide a means for intercellular communication and the transmission of bioactive compounds to targeted tissues, cells, and organs. These features have made them increasingly attractive as a therapeutic platform in recent years. However, there are many obstacles to designing EV-based therapeutics. In this review, we will outline the main hurdles and limitations for therapeutic and clinical applications of drug loaded EV formulations and describe various attempts to solve these problems.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
DOI：
10.1016/j.jconrel.2015.07.030
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Batrakova EV;Kim MS
通讯作者：
Kim MS
DOI：
10.1016/j.bbrc.2015.03.172
发表时间：
2015-05-22
影响因子：
3.1
作者：
Ban, Jae-Jun;Lee, Mijung;Kim, Manho
通讯作者：
Kim, Manho
影响因子：
5.5
作者：
Cai, Jinghua;Qiao, Bin;He, Wei
通讯作者：
He, Wei
影响因子：
5.1
作者：
Aryani A;Denecke B
通讯作者：
Denecke B