Differential effects of two fermentable carbohydrates on central appetite regulation and body composition.
Differential effects of two fermentable carbohydrates on central appetite regulation and body composition.
复制标题
两种可发酵碳水化合物对中央食欲调节和身体组成的差异影响。
DOI：
10.1371/journal.pone.0043263
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Frost G
中科院分区：
文献类型：
--
作者：
Arora T;Loo RL;Anastasovska J;Gibson GR;Tuohy KM;Sharma RK;Swann JR;Deaville ER;Sleeth ML;Thomas EL;Holmes E;Bell JD;Frost G
肥胖症在全球范围内正以惊人的速度上升。不同的可发酵碳水化合物已被证明可以减少肥胖。本研究的目的是研究两种不同的可发酵碳水化合物(菊粉和β-葡聚糖)对高脂饮食小鼠体成分和中枢食欲调节的影响是否相似。将36只C57BL/6雄性小鼠随机分为3组，分别饲喂含0%(w/w)可发酵碳水化合物、10%(w/w)菊粉和10%(w/w)β-葡聚糖的高脂饲料8周。用荧光原位杂交检测粪便和盲肠微生物的变化，用质子核磁共振(1HNMR)检测粪便代谢谱，用气相色谱测定结肠短链脂肪酸，用磁共振成像(MRI)和锰增强磁共振成像(MEMRI)分别测定体成分和下丘脑神经元的激活，用放射免疫法测定PYY(多肽YY)浓度，测量脂肪细胞的大小和数量。菊粉组和β-葡聚糖组的累积体重增加均显著低于高脂对照组。β-葡聚糖组小鼠的能量摄入量显著低于喂饲菊粉的小鼠，后者对总脂肪组织含量的影响最大。两组盲肠内容物和粪便中双歧杆菌和乳杆菌肠球菌的数量也有所增加。β-葡聚糖对弓状核、下丘脑腹内侧核、室旁核、室周核和孤束核的MEMRI相关神经元信号有明显的抑制作用，提示其处于饱和状态。虽然这两种可发酵的碳水化合物都可以防止体重增加，但菊粉引起的体内脂肪含量较低可能对新陈代谢有利。β-葡聚糖似乎抑制了下丘脑食欲中枢的神经元活动。可发酵碳水化合物的不同效应为营养靶向、食欲调节和身体组成打开了新的可能性。
Obesity is rising at an alarming rate globally. Different fermentable carbohydrates have been shown to reduce obesity. The aim of the present study was to investigate if two different fermentable carbohydrates (inulin and β-glucan) exert similar effects on body composition and central appetite regulation in high fat fed mice. Thirty six C57BL/6 male mice were randomized and maintained for 8 weeks on a high fat diet containing 0% (w/w) fermentable carbohydrate, 10% (w/w) inulin or 10% (w/w) β-glucan individually. Fecal and cecal microbial changes were measured using fluorescent in situ hybridization, fecal metabolic profiling was obtained by proton nuclear magnetic resonance (1H NMR), colonic short chain fatty acids were measured by gas chromatography, body composition and hypothalamic neuronal activation were measured using magnetic resonance imaging (MRI) and manganese enhanced MRI (MEMRI), respectively, PYY (peptide YY) concentration was determined by radioimmunoassay, adipocyte cell size and number were also measured. Both inulin and β-glucan fed groups revealed significantly lower cumulative body weight gain compared with high fat controls. Energy intake was significantly lower in β-glucan than inulin fed mice, with the latter having the greatest effect on total adipose tissue content. Both groups also showed an increase in the numbers of Bifidobacterium and Lactobacillus-Enterococcus in cecal contents as well as feces. β- glucan appeared to have marked effects on suppressing MEMRI associated neuronal signals in the arcuate nucleus, ventromedial hypothalamus, paraventricular nucleus, periventricular nucleus and the nucleus of the tractus solitarius, suggesting a satiated state. Although both fermentable carbohydrates are protective against increased body weight gain, the lower body fat content induced by inulin may be metabolically advantageous. β-glucan appears to suppress neuronal activity in the hypothalamic appetite centers. Differential effects of fermentable carbohydrates open new possibilities for nutritionally targeting appetite regulation and body composition.
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影响因子：
5.2
作者：
Choi, Joo Sun;Kim, Hyunsook;Song, Jihyun
通讯作者：
Song, Jihyun
影响因子：
2.9
作者：
Kuo, Yu-Ting;Herlihy, Amy H.;Bell, Jimmy D.
通讯作者：
Bell, Jimmy D.
DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI
影响因子：
4.1
作者：
Parkinson, James R. C.;Chaudhri, Owais B.;Bell, Jimmy D.
通讯作者：
Bell, Jimmy D.
影响因子：
4.8
作者：
le Roux, CW;Batterham, RL;Bloom, SR
通讯作者：
Bloom, SR