Intestinal barrier function in health and gastrointestinal disease.
Intestinal barrier function in health and gastrointestinal disease.
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DOI：
10.1111/j.1365-2982.2012.01921.x
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发表时间：
2012-06
影响因子：
3.5
通讯作者：
Verne GN
中科院分区：
文献类型：
--
作者：
Camilleri M;Madsen K;Spiller R;Greenwood-Van Meerveld B;Verne GN
肠道屏障功能缺陷与胃肠道疾病有关。越来越多的证据表明，肠道通透性增加在炎症性肠病(IBD)和乳糜泻等疾病以及功能性肠病(如肠易激综合征(IBS))中起致病作用。本文采用独特的翻译方法讨论IBS肠道屏障功能调节的生理和病理生理学机制。本文综述了肠道屏障的组成，包括肠上皮内的紧密连接复合体，以及在体外和体内用于评估肠道通透性的方法。在整个综述过程中，作者试图从实验动物模型和人体研究两方面对最新研究进行批判性回顾，以评估肠屏障功能障碍是否是功能性胃肠道疾病(如IBS)的主要原因。
Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo. Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS....
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DOI：
10.1152/ajpgi.00196.2010
发表时间：
2010-12-01
影响因子：
4.5
作者：
Chen, Hong-Qi;Yang, Jun;Qin, Huan-Long
通讯作者：
Qin, Huan-Long
影响因子：
7.6
作者：
Corinaldesi, R.;Stanghellini, V.;Barbara, G.
通讯作者：
Barbara, G.
影响因子：
29.4
作者：
Foley, Stephen;Garsed, Klara;Spiller, Robin C.
通讯作者：
Spiller, Robin C.
影响因子：
64.8
作者：
Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
通讯作者：
Ohno, Hiroshi
影响因子：
56.9
作者：
Farh, KKH;Grimson, A;Bartel, DP
通讯作者：
Bartel, DP