Helminth-Tuberculosis Co-infection: An Immunologic Perspective.

Helminth-Tuberculosis Co-infection: An Immunologic Perspective.
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DOI:
10.1016/j.it.2016.07.005
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发表时间:
2016-09
影响因子:
16.8
通讯作者:
Nutman TB
Nutman TB
中科院分区:
医学1区
文献类型:
--
作者:
Babu S;Nutman TB

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全世界有超过20亿人感染蠕虫(蠕虫)。类似地,结核分枝杆菌(Mtb)感染发生在超过三分之一的世界人口中,通常与蠕虫感染有很大程度的地理重叠。有趣的是,由细胞外蠕虫诱导的反应和由细胞内Mtb诱导的反应通常是相互拮抗的,因此,可能导致宿主对感染病原体的反应受损(或交叉调节)。在这篇综述中,我们概述了蠕虫和结核病(TB)感染诱导的免疫反应的性质,然后提供实验模型和人体研究的数据,说明蠕虫寄生虫产生的免疫反应如何调节蠕虫-TB共感染中的MTB特异性反应。
Over 2 billion people worldwide are infected with helminths (worms). Similarly, infection with Mycobacterium tuberculosis (Mtb) occurs in over a third of the world's population, often with a great degree of geographical overlap with helminth infection. Interestingly, the responses induced by the extracellular helminths and those induced by the intracellular Mtb are often mutually antagonistic and, as a consequence, can result in impaired (or cross-regulated) host responses to either of the infecting pathogens. In this review, we outline the nature of the immune responses induced by infections with helminths and tuberculosis (TB) and then provide data from both experimental models and human studies that illustrate how the immune response engendered by helminth parasites modulates Mtb-specific responses in helminth-TB co-infection.
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发表时间: 2014-08
影响因子: 2.2
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