Immunology of lymphatic filariasis.
Immunology of lymphatic filariasis.
复制标题
DOI：
10.1111/pim.12081
复制
发表时间：
2014-08
影响因子：
2.2
通讯作者：
Nutman TB
中科院分区：
文献类型：
--
作者：
Babu S;Nutman TB
对丝虫病寄生虫的免疫反应包括先天和适应性细胞的复杂网络，它们与寄生虫的相互作用是一系列临床表现的基础。淋巴丝虫病的主要免疫学特征是抗原特异性Th2反应和IL-10产生CD4+ T细胞的扩增，并伴有沉默的Th1反应。这种抗原特异性T细胞的低反应性似乎是维持持续、长期感染的关键，通常伴有高寄生虫密度。虽然保护性免疫对淋巴丝虫病的相关性仍然不完全清楚，主要是由于缺乏合适的动物模型来研究易感性，但很明显，T细胞和一定程度上的B细胞是保护性免疫所必需的。宿主免疫反应，特别是CD4+ T细胞反应在淋巴水肿、鞘膜积液、象皮病等LF病理表现中明显起作用。临床病理发展的主要潜在缺陷似乎是在面对抗原刺激时未能诱导T细胞低反应性。最后，丝虫感染的另一个有趣的特征是它们倾向于诱导各种免疫反应的旁观者效应，包括对疫苗接种，过敏原和其他感染因子的反应。因此，丝虫感染免疫反应的复杂性为理解慢性感染免疫反应的调节提供了一个重要的途径。
The immune responses to filarial parasites encompass a complex network of innate and adaptive cells whose interaction with the parasite underlies a spectrum of clinical manifestations. The predominant immunological feature of lymphatic filariasis is an antigen - specific Th2 response and an expansion of IL-10 producing CD4+ T cells that is accompanied by a muted Th1 response. This antigen specific T cell hypo-responsiveness appears to be crucial for the maintenance of the sustained, long-standing infection often with high parasite densities. While the correlates of protective immunity to lymphatic filariasis are still incompletely understood, primarily due to the lack of suitable animal models to study susceptibility, it is clear that T cells and to a certain extent B cells are required for protective immunity. Host immune responses, especially CD4+ T cell responses clearly play a role in mediating pathological manifestations of LF, including lymphedema, hydrocele and elephantiasis. The main underlying defect in the development of clinical pathology appears to be a failure to induce T cell hypo-responsiveness in the face of antigenic stimulation. Finally, another intriguing feature of filarial infections is their propensity to induce bystander effects on a variety of immune responses, including responses to vaccinations, allergens and to other infectious agents. The complexity of the immune response to filarial infection therefore provides an important gateway to understanding the regulation of immune responses to chronic infections, in general.
登录
查看更多内容
影响因子：
6.7
作者：
Anuradha R;George PJ;Pavan Kumar N;Fay MP;Kumaraswami V;Nutman TB;Babu S
通讯作者：
Babu S
影响因子：
30.8
作者：
Desjardins, Christopher A.;Cerqueira, Gustavo C.;Goldberg, Jonathan M.;Hotopp, Julie C. Dunning;Haas, Brian J.;Zucker, Jeremy;Ribeiro, Jose M. C.;Saif, Sakina;Levin, Joshua Z.;Fan, Lin;Zeng, Qiandong;Russ, Carsten;Wortman, Jennifer R.;Fink, Doran L.;Birren, Bruce W.;Nutman, Thomas B.
通讯作者：
Nutman, Thomas B.
影响因子：
6.7
作者：
Debrah, Alexander Yaw;Mand, Sabine;Hoerauf, Achim
通讯作者：
Hoerauf, Achim
DOI：
10.4269/ajtmh.2009.80.956
发表时间：
2009-06-01
影响因子：
3.3
作者：
Debrah, Alexander Y.;Mand, Sabine;Hoerauf, Achim
通讯作者：
Hoerauf, Achim
影响因子：
6.4
作者：
Babu, Subash;Kumaraswami, V.;Nutman, Thomas B.
通讯作者：
Nutman, Thomas B.