Simplification and desexualization of gene expression in self-fertile nematodes.
Simplification and desexualization of gene expression in self-fertile nematodes.
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DOI：
10.1016/j.cub.2012.09.038
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发表时间：
2012-11-20
期刊：
影响因子：
9.2
通讯作者：
Haag, Eric S.
中科院分区：
文献类型：
--
作者：
Thomas, Cristel G.;Li, Renhua;Smith, Harold E.;Woodruff, Gavin C.;Oliver, Brian;Haag, Eric S.
性模式之间的进化转换可能是基因组进化的强大力量。一些小杆线虫物种已经从它们祖先的专性异交雌性进化出自育雌雄同体。通过比较两个自交种，即白腹锦鸡儿（C.和秀丽隐杆线虫C. briggsae，具有3个遗传信息丰富的异交近缘种，C. japonica、日本刺蛾C. brenneri和C.日本的。成年人的转录组组件从自交物种是一贯的和显着小于那些异交物种。在这种整体简化的背景下，在多个异交物种中具有强烈性别偏见表达的保守基因更有可能从自交物种的基因组中缺失。此外，其余的成绩单的性调节已经偏离了显着的祖先模式在两个自交系，但在不同的方式。因此，transciptomes的复杂性和性特化都迅速改变，以响应自我生育的进化。这些变化可能是由于结合宽松的性选择和最近报道的遗传机制，有利于基因组收缩部分selfers。
Evolutionary transitions between sexual modes could be potent forces in genome evolution. Several Caenorhabditis nematode species have evolved self-fertile hermaphrodites from the obligately outcrossing females of their ancestors. We explored the relationship between sexual mode and global gene expression by comparing two selfing species, C. elegans and C. briggsae, with three phylogenetically informative outcrossing relatives, C. japonica, C. brenneri, and C. japonica. Adult transcriptome assemblies from the selfing species are consistently and strikingly smaller than those of the outcrossing species. Against this background of overall simplification, genes conserved in multiple outcrossing species with strong sex-biased expression are even more likely to be missing from the genomes of the selfing species. In addition, the sexual regulation of remaining transcripts has diverged markedly from the ancestral pattern in both selfing lineages, though in distinct ways. Thus, both the complexity and the sexual specialization of transciptomes are rapidly altered in response to the evolution of self-fertility. These changes may result from the combination of relaxed sexual selection and a recently reported genetic mechanism favoring genome shrinkage in partial selfers.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1073/pnas.1108068108
发表时间：
2011-12-06
影响因子：
11.1
作者：
Beadell, Alana V.;Liu, Qinwen;Haag, Eric S.
通讯作者：
Haag, Eric S.