Prevalence and risk factors for fatigue among breast cancer survivors on aromatase inhibitors.
Prevalence and risk factors for fatigue among breast cancer survivors on aromatase inhibitors.
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使用芳香酶抑制剂的乳腺癌幸存者中疲劳的患病率和危险因素
DOI：
10.1016/j.ejca.2018.06.009
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Mao JJ
中科院分区：
文献类型：
--
作者：
Mao H;Bao T;Shen X;Li Q;Seluzicki C;Im EO;Mao JJ
疲劳是癌症幸存者最常见和最痛苦的症状。本研究旨在确定接受芳香酶抑制剂（AIs）治疗的乳腺癌（BC）幸存者中疲劳的患病率和危险因素。我们对一家大型大学医院乳腺肿瘤门诊接受辅助人工智能治疗的0 - III期乳腺癌绝经后妇女进行了一项横断面调查研究。在简短疲劳量表（BFI）中“最严重疲劳”项得分≥4分的参与者被归类为中度或重度疲劳。多因素logistic回归分析评估危险因素。在1103名参与者中，616名（55.8%）有中度或重度疲劳。在多变量logistic回归模型中，55岁以下的女性报告中重度疲劳的可能性显著高于65岁以上的女性(调整优势比（AOR）， 1.58, 95%可信区间（CI） 1.07-2.35；p = 0.023)。与受过高中或更低教育的女性相比，受过大学或更高教育的女性更有可能报告中度至重度疲劳（AOR, 1.40, 95% CI 1.02-1.91; p=0.037）。体重指数（BMI）的增加与出现中重度疲劳的风险增加显著相关（超重：AOR， 1.37, 95% CI 1.01-1.84; p=0.042；肥胖：AOR， 2.08, 95% CI 1.53-2.81; p<0.001）。疲劳与疼痛严重程度（r=0.48, p<0.001）和失眠（r=0.62, p<0.001）显著相关。在人工智能用户中，中重度疲劳投诉超过50%。疲劳与年龄小、受教育程度高、身体质量指数高、疼痛严重程度和失眠密切相关。
Fatigue is the most common and distressing symptom experienced by cancer survivors. This study sought to determine the prevalence and risk factors for fatigue among breast cancer (BC) survivors receiving aromatase inhibitors (AIs). We conducted a cross-sectional survey study among postmenopausal women with stage 0 to III BC receiving adjuvant AI therapy at the outpatient breast oncology clinic of a large university hospital. Participants with a score ≥4 on the “worst fatigue” item of the Brief Fatigue Inventory (BFI) were classified as having moderate or severe fatigue. Multivariate logistic regression analyses were performed to evaluate risk factors. Among 1,103 participants, 616 (55.8%) had moderate or severe fatigue. In the multivariate logistic regression model, women younger than 55 years were significantly more likely to report moderate-severe fatigue than women older than 65 years (adjusted odds ratio (AOR), 1.58, 95% confidence interval (CI) 1.07–2.35; p=0.023). Compared to women with high school or less education, women with college or more education were significantly more likely to report moderate-severe fatigue (AOR, 1.40, 95% CI 1.02–1.91; p=0.037). Increasing body mass index (BMI) was significantly associated with increased risk of experiencing moderate-severe fatigue (overweight: AOR, 1.37, 95% CI 1.01–1.84; p=0.042; obesity: AOR, 2.08, 95% CI 1.53–2.81; p<0.001). Fatigue was significantly correlated with pain severity (r=0.48, p<0.001) and insomnia (r=0.62, p<0.001). Moderate-severe fatigue complaints exceed 50% among AI users. Fatigue is highly related to younger age, higher education level, higher BMI, pain severity, and insomnia.
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影响因子：
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影响因子：
6.2
作者：
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