Biomarkers for sepsis: a review with special attention to India.

Biomarkers for sepsis: a review with special attention to India.
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DOI:
10.1155/2014/264351
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发表时间:
2014
影响因子:
--
通讯作者:
Gupta A
Gupta A
中科院分区:
生物学3区
文献类型:
--
作者:
Nelson GE;Mave V;Gupta A

文献摘要

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败血症是一种严重的感染,在印度等资源有限的环境中仍然是发病和死亡的常见原因。即使可以进行微生物学诊断,也只能在一定比例的败血症和血液感染患者中发现菌血症。生物标志物已被用于各种疾病过程,可以帮助诊断细菌感染。已经研究了许多生物标志物,以帮助诊断和预测败血症,但大多数缺乏敏感性或特异性。降钙素原被认为是治疗血液感染最有希望的生物标志物。数据正在印度涌现,在这篇综述中,我们关注败血症中生物标志物的当前数据,特别关注生物标志物如何在印度用于增强诊断和治疗。
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections. Biomarkers have been used in a variety of disease processes and can help aid in diagnosing bacterial infections. There have been numerous biomarkers investigated to aid with diagnosis and prognostication in sepsis with the majority suffering from lack of sensitivity or specificity. Procalcitonin has been heralded as the biomarker that holds the most promise for bloodstream infections. Data are emerging in India, and in this review, we focus on the current data of biomarkers in sepsis with particular attention to how biomarkers could be used to augment diagnosis and treatment in India.
从2009年H1N1病毒性肺炎开始,促阳性素和C反应蛋白在分化混合细菌感染中的作用。
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