APOE genotype and functional outcome following aneurysmal subarachnoid hemorrhage.
APOE genotype and functional outcome following aneurysmal subarachnoid hemorrhage.
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DOI：
10.1177/1099800408323221
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发表时间：
2009-01
影响因子：
2.5
通讯作者：
Alexander SA
中科院分区：
文献类型：
--
作者：
Gallek MJ;Conley YP;Sherwood PR;Horowitz MB;Kassam A;Alexander SA
载脂蛋白E（apoE）是中枢神经系统中的主要载脂蛋白，已被证明以基因特异性方式影响神经系统疾病的进展和对神经系统损伤的反应。APOE4等位基因的存在与创伤性脑损伤和缺血性卒中的不良反应相关，但APOE基因型与蛛网膜下腔出血（SAH）后结局之间的关系尚不清楚。本研究旨在探讨APOE基因型与SAH预后的关系。我们还探讨了APOE4基因型和脑血管痉挛（CV）的存在，在我们的人口与可用的血管造影数据的子样本的关联。对206例蛛网膜下腔出血患者进行了APOE基因分型，并在动脉瘤破裂后3个月和6个月收集了格拉斯哥结局评分（GOS）和改良兰金评分（MRS）。APOE4基因型的存在与控制年龄、种族、出血量（Fisher分级）和损伤严重程度（Hunt & Hess分级）的功能结局之间没有显著相关性。然而，当控制CV和协变量时，携带APOE4等位基因的个体在两个时间点的功能结局均较差。即使考虑到CV的存在，APOE2等位基因的存在也与功能结局无关。与APOE4存在、APOE2存在或CV存在相关的死亡率无差异。这些结果表明APOE4等位基因与蛛网膜下腔出血后不良结局相关。
Apolipoprotein E (apoE), the major apolipoprotein in the central nervous system, has been shown to influence neurologic disease progression and response to neurologic injury in a gene-specific manner. Presence of the APOE4 allele is associated with poorer response to traumatic brain injury and ischemic stroke, but the association between APOE genotype and outcome following aneurysmal subarachnoid hemorrhage (SAH) remains unclear. The purpose of this project was to investigate the association between APOE genotype and outcome after SAH. We also explored the association of APOE4 genotype and cerebral vasospasm (CV) presence in a subsample of our population with available angiographic data. A sample of 206 aneurysmal SAH participants had APOE genotyping performed, Glasgow outcome scores (GOS) and modified Rankin scores (MRS) collected at 3 and 6 months after aneurysm rupture. No significant association was found between the presence of the APOE4 genotype and functional outcomes controlling for age, race, size of hemorrhage (Fisher grade), and severity of injury (Hunt & Hess grade). However when controlling for CV and the covariates listed above, individuals with the APOE4 allele had worse functional outcomes at both time points. The presence of the APOE2 allele was not associated with functional outcomes even when considering presence of CV. There was no difference in mortality associated with APOE4 presence, APOE2 presence, or presence of CV. These findings suggest APOE4 allele is associated with poor outcome after aneurysmal SAH.
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影响因子：
56.9
作者：
MAHLEY, RW
通讯作者：
MAHLEY, RW
影响因子：
4.1
作者：
MAAS, AIR;BRAAKMAN, R;VANZOMEREN, AH
通讯作者：
VANZOMEREN, AH
影响因子：
4.2
作者：
Isoniemi, Heli;Tenovuo, Olli;Kairisto, Veli
通讯作者：
Kairisto, Veli
影响因子：
11.4
作者：
JENNETT, B
通讯作者：
JENNETT, B
影响因子：
11.2
作者：
GENNARELLI, TA;THIBAULT, LE;MARCINCIN, RP
通讯作者：
MARCINCIN, RP