Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6.
Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6.
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DOI：
10.1007/s10571-020-00902-6
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发表时间：
2021-08
影响因子：
4
通讯作者：
Roberts A
中科院分区：
文献类型：
--
作者：
Gruol DL;Hernandez RV;Roberts A
最近的研究表明，酒精暴露可诱导中枢神经系统神经免疫因子的神经胶质细胞产生。其中，IL-6参与了许多重要的生理和病理生理过程，酒精诱导的中枢神经系统产生IL-6可能影响到IL-6的产生，尤其是在过度饮酒的情况下。例如，IL-6已被证明在与记忆和学习相关的海马区行为和突触可塑性(长时程增强；LTP)中发挥作用。令人惊讶的是，在我们的体外研究中，在海马区CA1锥体神经元突触的Schaffer侧支的LTP来自表达高水平的星形胶质细胞产生IL-6(TG)的转基因小鼠，LTP没有因IL-6水平的提高而改变。然而，急性酒精暴露显示了神经适应性的变化，这些变化有助于保护LTP免受酒精诱导的非转基因对照小鼠(WT)海马区LTP的减少。在这里，我们研究了LTP的诱导阶段，以评估在TG小鼠的海马区是否发生了突触前神经适应性变化，这些变化有助于LTP对酒精的抵抗力。结果与IL-6诱导的神经适应效应在突触前机制中的作用是一致的，该机制涉及递质释放在Tg小鼠海马区LTP对酒精的抵抗中。这些作用对于IL-6在中枢神经系统的生理和病理生理过程中的作用以及在中枢神经系统中酒精的作用是重要的，特别是当过量饮酒与中枢神经系统中IL-6水平升高的情况并存时。
Recent studies show that alcohol exposure can induce glial production of neuroimmune factors in the CNS. Of these, IL-6 has gained attention because it is involved in a number of important physiological and pathophysiological processes that could be affected by alcohol-induced CNS production of IL-6, particularly under conditions of excessive alcohol use. For example, IL-6 has been shown to play a role in hippocampal behaviors and synaptic plasticity (long-term potentiation; LTP) associated with memory and learning. Surprisingly, in our in vitro studies of LTP at the Schaffer collateral to CA1 pyramidal neuron synapse in hippocampus from transgenic mice that express elevated levels of astrocyte produced IL-6 (TG), LTP was not altered by the increased levels of IL-6. However, exposure to acute alcohol revealed neuroadaptive changes that served to protect LTP against the alcohol-induced reduction of LTP observed in hippocampus from non-transgenic control mice (WT). Here we examined the induction phase of LTP to assess if presynaptic neuroadaptive changes occurred in the hippocampus of the TG mice that contributed to the resistance of LTP to alcohol. Results are consistent with a role for IL-6 induced neuroadaptive effects on presynaptic mechanisms involved in transmitter release in the resistance of LTP to alcohol in hippocampus from the TG mice. These actions are important with respect to a role for IL-6 in physiological and pathophysiological processes in the CNS and in CNS actions of alcohol, especially when excessive alcohol used is co-morbid with conditions associated with elevated levels of IL-6 in the CNS.
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影响因子：
13.8
作者：
Cui C;Koob GF
通讯作者：
Koob GF
影响因子：
3.3
作者：
Anderson ML;Nokia MS;Govindaraju KP;Shors TJ
通讯作者：
Shors TJ
每天但不是间歇性酒精暴露后，神经免疫性基因表达的持续改变。
影响因子：
2.9
作者：
Gano A;Doremus-Fitzwater TL;Deak T
通讯作者：
Deak T
影响因子：
5.3
作者：
Alfonso-Loeches, Silvia;Pascual-Lucas, Maya;Guerri, Consuelo
通讯作者：
Guerri, Consuelo
影响因子：
3.4
作者：
Alleva, E;Cirulli, F;Panerai, AE
通讯作者：
Panerai, AE