Comparative toxicology of mercurials in Caenorhabditis elegans.
Comparative toxicology of mercurials in Caenorhabditis elegans.
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DOI：
10.1002/etc.603
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发表时间：
2011-09
影响因子：
4.1
通讯作者：
Freedman, Jonathan H.
中科院分区：
文献类型：
--
作者：
McElwee, Matthew K.;Freedman, Jonathan H.
汞是一种有毒金属，可以以多种化学物质存在。人类通常暴露于甲基汞和汞蒸气，汞蒸气在体内转化为汞。尽管多年的研究，有一个关于汞毒性机制的相似性和差异的信息很少。本文研究了氯化汞（HgCl_2）和氯化甲基汞（MeHgCl）对C.使用测量生长、进食、繁殖和运动的测定来确定线虫。HgCl 2和MeHgCl对几个原型的压力反应基因的表达的影响也被确定。两种汞剂对C. elegans生长MeHgCl对C.在评估进食、运动和繁殖时，线虫比HgCl 2更敏感，所有这些都需要适当的神经肌肉活动。氯化甲基汞暴露导致应激反应基因的稳态水平增加，浓度低于氯化汞。总的来说，MeHgCl对C.比HgCl2更优雅，特别是在测定需要神经肌肉功能的行为时。
Mercury is a toxic metal that can exist in multiple chemical species. Humans are commonly exposed to methylmercury and mercury vapor, which is converted to mercuric mercury in the body. Despite years of research, there is a paucity of information on the similarity and differences in the mechanisms of mercury toxicity. The relative toxicity of mercuric chloride (HgCl2) and methylmercury chloride (MeHgCl) in C. elegans was determined using assays that measured growth, feeding, reproduction, and locomotion. The effect of HgCl2 and MeHgCl on the expression of several archetypal stress-response genes was also determined. There was no significant difference between the EC50s of the two mercurials on C. elegans growth. However, MeHgCl was more toxic to C. elegans than HgCl2 when assessing feeding, movement and reproduction, all of which require proper neuromuscular activity. Methylmercury chloride exposure resulted in increased steady-state levels of the stress response genes at lower concentrations than HgCl2. In general, MeHgCl was more toxic to C. elegans than HgCl2, particularly when assaying behaviors that require neuromuscular function.
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影响因子：
3.8
作者：
Boyd WA;McBride SJ;Rice JR;Snyder DW;Freedman JH
通讯作者：
Freedman JH
影响因子：
3.4
作者：
Kaur, Parvinder;Aschner, Michael;Syversen, Tore
通讯作者：
Syversen, Tore
影响因子：
3.5
作者：
Liao, VHC;Yu, CW
通讯作者：
Yu, CW
影响因子：
3.8
作者：
Hasegawa, Koichi;Miwa, Satsuki;Miwa, Johji
通讯作者：
Miwa, Johji
DOI：
10.1007/s00244-004-0031-2
发表时间：
2005-05-01
影响因子：
4
作者：
Graves, AL;Boyd, WA;Williams, PL
通讯作者：
Williams, PL