A conserved tooth resorption mechanism in modern and fossil snakes.

A conserved tooth resorption mechanism in modern and fossil snakes.
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DOI:
10.1038/s41467-023-36422-2
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发表时间:
2023-02-10
影响因子:
16.6
通讯作者:
Caldwell, M. W.
Caldwell, M. W.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
LeBlanc, A. R. H.;Palci, A.;Anthwal, N.;Tucker, A. S.;Araujo, R.;Pereira, M. F. C.;Caldwell, M. W.

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蛇是先进化出细长的、无肢体的身体,还是先进化出专门的头骨和牙齿,这是有鳞动物进化过程中的一个中心问题。因此,识别现存的蛇和化石蛇之间的共同特征是解开这一标志性爬行动物群体早期进化的关键。一个很有希望的候选者是他们不同寻常的牙齿替换模式,即在没有外部牙齿吸收迹象的情况下进行牙齿替换。我们通过组织学分析揭示,蛇缺乏吸收坑是由于破牙细胞的异常行为,它从牙髓中吸收牙本质。内牙吸收在现存的蛇中广泛存在,不同于其他爬行动物的替换,甚至可以通过非破坏性的μCT扫描检测到,这为识别蛇化石提供了一种方法。然后,我们在蛇化石尤伦古尔和最古老的蛇化石之一葡萄牙蛇中发现了内部牙齿吸收,这表明它是泛蛇化石中最早的创新之一,可能先于肢体丧失。活着的蛇在没有外部吸收的情况下更换了牙齿。在这里,作者使用组织学来证明破牙细胞在内部吸收牙本质,并在蛇化石中研究这一机制。
Whether snakes evolved their elongated, limbless bodies or their specialized skulls and teeth first is a central question in squamate evolution. Identifying features shared between extant and fossil snakes is therefore key to unraveling the early evolution of this iconic reptile group. One promising candidate is their unusual mode of tooth replacement, whereby teeth are replaced without signs of external tooth resorption. We reveal through histological analysis that the lack of resorption pits in snakes is due to the unusual action of odontoclasts, which resorb dentine from within the pulp of the tooth. Internal tooth resorption is widespread in extant snakes, differs from replacement in other reptiles, and is even detectable via non-destructive μCT scanning, providing a method for identifying fossil snakes. We then detected internal tooth resorption in the fossil snake Yurlunggur, and one of the oldest snake fossils, Portugalophis, suggesting that it is one of the earliest innovations in Pan-Serpentes, likely preceding limb loss. Living snakes replace their teeth without external resorption. Here, the authors use histology to show that odontoclasts resorb dentine internally and investigate this mechanism in fossil snakes.
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