Resilient phenotypes among bereaved youth: a comparison of trajectory, relative, and cross-domain approaches.

Resilient phenotypes among bereaved youth: a comparison of trajectory, relative, and cross-domain approaches.
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DOI:
10.1186/s13034-023-00568-0
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发表时间:
2023-02-08
影响因子:
5.6
通讯作者:
Denckla, Christy. A. A.
Denckla, Christy. A. A.
中科院分区:
医学3区
文献类型:
--
作者:
Dice, Ana Lucia Espinosa;Ye, Xian;Kim, Stephanie Gyuri;McLaughlin, Katie A.;Amstadter, Ananda. B. B.;Tiemeier, Henning;Denckla, Christy. A. A.

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丧亲之痛是一种常见的创伤性事件,与整个生命过程中的不良健康结果有关。尽管存在这些风险,但并非所有失去亲人的人都会经历这些负面影响。关于如何定义经历过亲人死亡的个体的复原力,科学界存在有限的共识。使用样本N = 3766青少年雅芳纵向研究的父母和儿童出生队列,我们确定了丧亲的家庭成员之间的年龄7和8.5。我们得出并比较了三种不同的方法来评估失去亲人的青年的韧性。基于轨迹的心理弹性确定了6至16岁之间具有相似心理症状的亚组,使用潜在增长混合模型。16岁时的相对心理弹性利用了一个模型的标准化残差,该模型回归了丧亲心理症状,以确定与丧亲状态相关的优于预期的心理功能。16岁左右的相对跨域弹性是应用于8个独特健康领域的残差方法的总和。在17.5岁时使用抑郁症状评估每种方法的预测有效性。总体而言,N = 877(23%)名青年在7岁至8.5岁之间失去了家庭成员。使用潜在增长混合模型,一个三级解决方案描述了84%的丧亲青年随着时间的推移具有较低和稳定的心理症状,8%的症状恶化,8%的症状改善但升高。每个相对弹性得分在很大程度上是一致的,以确定个人为弹性或不,虽然相对心理弹性表现出更强的一致性程度比跨域得分的基于概率的方法。相对心理和跨域弹性表现出中度至低度相关,这取决于所包括的域(r = 0.14-0.43)。对于每种方法,弹性显着预测17.5岁时较低的抑郁症状,突出了这些措施的预测有效性。失去亲人的青年的心理症状轨迹与先前在失去亲人的成年人中确定的心理症状轨迹一致。以剩余物为基础的复原力定义方法在丧亲之痛的情况下效用有限。在确定丧亲后的风险和复原力时,研究人员和临床医生必须解决心理社会和身体健康领域的相互作用,因为从心理健康角度来看,被认为具有复原力的丧亲青年可能会从其他领域的干预中受益。在线版本包含补充材料,可通过10.1186/s13034-023-00568-0获得。
Bereavement is a common traumatic event associated with adverse health outcomes across the life course. Despite these risks, not all bereaved individuals experience these negative effects. Limited scientific consensus exists on how to define resilience in individuals who have experienced the death of a loved one. Using a sample of N = 3766 youth from the Avon Longitudinal Study of Parents and Children birth cohort, we identified bereavement of a family member between ages 7 and 8.5. We derived and compared three different approaches to assess resilience among bereaved youth. Trajectory-based psychological resilience identified sub-groups with similar psychological symptom profiles between ages 6 and 16 using latent growth mixture models. Relative psychological resilience at age 16 leveraged standardized residuals from a model regressing psychological symptoms on bereavement to determine better-than-expected psychological functioning relative to bereavement status. Relative cross-domain resilience around age 16 was a sum score of the residuals approach applied to eight unique domains of health. Predictive validity of each approach was assessed using depressive symptoms at age 17.5 Overall, N = 877 (23%) youth were bereaved of a family member between ages 7 and 8.5. Using latent growth mixture models, a three-class solution described 84% of bereaved youth with low and stable psychological symptoms over time, 8% with worsening symptoms, and 8% with improving yet elevated symptoms. Each relative resilience score was largely concordant with the trajectory-based approach in identifying individuals as resilient or not, though relative psychological resilience demonstrated a stronger degree of concordance than the cross-domain score. Relative psychological and cross-domain resilience exhibited moderate to low correlation, depending on the domains included (r = 0.14–0.43). For each approach, resilience significantly predicted lower depressive symptoms at age 17.5, highlighting predictive validity of these measures. Psychological symptom trajectories among bereaved youth aligned with those previously identified among bereaved adults. The residual-based approach to defining resilience exhibited limited utility in the context of bereavement. When identifying risk and resilience after bereavement, researchers and clinicians must address the interplay across psychosocial and physical health domains, as bereaved youth considered resilient from a mental health perspective may benefit from intervention in other domains. The online version contains supplementary material available at 10.1186/s13034-023-00568-0.
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