Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report.
Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report.
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肝癌并发慢性粒细胞白血病和极度血小板增多症：罕见病例报告
DOI：
10.1177/03000605221123684
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发表时间：
2022-09
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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慢性粒细胞白血病(CML)可在实体瘤的长期化疗后偶尔发生；CML的化疗和生物治疗继发的实体瘤也有报道。然而，在未经治疗的患者中同时出现这两种现象的报道很少。在此，我们描述了一例60岁出头的女性患者S，她在发现肝脏肿块和血浆甲胎蛋白水平升高后被转送到肝脏外科。她最初被诊断出患有肝癌。血检显示血小板计数升高(2464 × 109/L)。骨髓活检的染色体检查显示存在t(9；22)易位，随后的荧光原位杂交和聚合酶链式反应对bcr-abl重排呈阳性。诊断为慢性粒细胞白血病。患者接受了羟基脲和伊马替尼治疗CML，随后接受了血小板降低治疗和肝脏活检，提示为中低分化腺癌或潜在的肝转移癌。然而，患者拒绝进一步的病理检查或对原发肿瘤的部位进行筛查。她在出院后6.5个月去世。这两种肿瘤之间的确切关系尚不清楚，更多的患者需要评估。
Chronic myelocytic leukemia (CML) can occasionally occur after long-term chemotherapy for solid tumors; solid tumors secondary to chemotherapy and biotherapy for CML have also been reported. However, concurrence of these two phenomena in an untreated patient has seldom been reported. Herein, we describe the case of a female patient in her early 60 s who was transferred to the liver surgery department after the discovery of a large liver mass and elevated plasma alpha-fetoprotein levels. She was initially diagnosed with liver cancer. Blood tests indicated an increased platelet count (2464 × 109/L). Chromosomal examination from a bone marrow biopsy indicated the presence of the t(9;22) translocation, and subsequent fluorescence in situ hybridization and PCR were positive for the BCR-ABL rearrangement. A diagnosis of CML was made. The patient received hydroxyurea and imatinib to treat CML and underwent subsequent platelet-lowering therapy and a liver biopsy, which suggested moderately poorly differentiated adenocarcinoma or potentially hepatic metastatic carcinoma. However, the patient refused further pathological examination or screening for the site of the primary tumor. She died 6.5 months after discharge. The exact relationship between the two tumors remains unclear, and more patients need to be evaluated.
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影响因子：
1.2
作者：
Tsuzuki, Motohiro;Handa, Kousuke;Ezaki, Kohji
通讯作者：
Ezaki, Kohji
影响因子：
37.3
作者：
Soverini S;Mancini M;Bavaro L;Cavo M;Martinelli G
通讯作者：
Martinelli G
影响因子：
2.1
作者：
Chiba, Akira;Toya, Takashi;Kurokawa, Mineo
通讯作者：
Kurokawa, Mineo
DOI：
10.1097/01.coc.0000143845.79889.33
发表时间：
2005-04-01
影响因子：
2.6
作者：
Pavithran, K;Doval, DC
通讯作者：
Doval, DC
影响因子：
2.7
作者：
Waller, CF;Fetscher, S;Lange, W
通讯作者：
Lange, W