Eosinophilic Gastrointestinal Diseases: The Pathogenesis, Diagnosis, and Treatment.
Eosinophilic Gastrointestinal Diseases: The Pathogenesis, Diagnosis, and Treatment.
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嗜酸性胃肠道疾病：发病机理，诊断和治疗。
DOI：
10.2169/internalmedicine.8417-21
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发表时间：
2023-01-01
影响因子：
1.2
通讯作者：
Oouchi, Sachiko
中科院分区：
文献类型：
--
作者：
Kinoshita, Yoshikazu;Yahata, Shinsuke;Oouchi, Sachiko
嗜酸性胃肠道疾病是一种迟发性慢性变态反应性疾病，表现为胃肠道嗜酸性粒细胞密集浸润，Th2型免疫反应过度被认为是其重要机制。这些疾病大致可分为两种类型：嗜酸性食管炎，主要见于青年和中年男性，以及嗜酸性胃肠炎，男女比例相同。嗜酸性食管炎的诊断是当注意到包括纵向皱纹和环状在内的特征性内窥镜表现时。然而，在嗜酸性胃肠炎患者中很少发现特征性的内窥镜异常，因此从表面正常的胃肠粘膜表面进行多次活检采样对于做出准确的诊断是重要的。全身应用糖皮质激素是嗜酸性胃肠炎的标准治疗方法，而酸抑制剂和局部糖皮质激素吞咽疗法对嗜酸性食管炎有效。针对嗜酸性胃肠道疾病的抗细胞因子疗法目前正在开发中。
Eosinophilic gastrointestinal diseases are delayed-type chronic allergic disorders that show gastrointestinal eosinophil dense infiltration, with an exaggerated Th2-type immune reaction considered to be an important mechanism. These diseases can be roughly divided into two types: eosinophilic esophagitis, mainly found in young and middle-aged men, and eosinophilic gastroenteritis, which is found in both genders equally. A diagnosis of eosinophilic esophagitis is suspected when characteristic endoscopic findings, including longitudinal furrows and rings, are noted. However, characteristic endoscopic abnormalities are rarely found in cases with eosinophilic gastroenteritis, so multiple biopsy sampling from the apparently normal gastrointestinal mucosal surface is important for making an accurate diagnosis. The administration of systemic glucocorticoid is the standard treatment for eosinophilic gastroenteritis, while acid inhibitors and topical glucocorticoid swallowing therapy are effective for eosinophilic esophagitis. Anti-cytokine therapies for eosinophilic gastrointestinal diseases are currently under development.
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DOI：
10.15403/jgld.2014.1121.242.bsy
发表时间：
2015-06
期刊：
Journal of gastrointestinal and liver diseases : JGLD
影响因子：
--
作者：
Dellon ES;Yellore V;Andreatta M;Stover J
通讯作者：
Stover J
影响因子：
2.4
作者：
Furuta K;Adachi K;Aimi M;Ishimura N;Sato S;Ishihara S;Kinoshita Y
通讯作者：
Kinoshita Y
影响因子：
29.4
作者：
Gonsalves, Nirmala;Yang, Guang-Yu;Hirano, Ikuo
通讯作者：
Hirano, Ikuo
影响因子：
9.8
作者：
Ackerman, Steven J.;Kagalwalla, Amir F.;Furuta, Glenn T.
通讯作者：
Furuta, Glenn T.
影响因子：
14.2
作者：
Allen-Brady, Kristina;Firszt, Rafael;Peterson, Kathryn A.
通讯作者：
Peterson, Kathryn A.