Brain Oxytocin in Social Fear Conditioning and Its Extinction: Involvement of the Lateral Septum
Brain Oxytocin in Social Fear Conditioning and Its Extinction: Involvement of the Lateral Septum
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大脑催产素在社交恐惧调节及其消除中的作用：侧隔膜的参与
DOI：
10.1038/npp.2014.156
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发表时间：
2014
影响因子：
7.6
通讯作者：
Neumann ID
中科院分区：
文献类型：
--
作者：
Zoicas I;Slattery DA;Neumann ID
中枢催产素(OXT)在人类和啮齿动物身上都具有抗焦虑和亲社会的特性，已被认为是治疗焦虑和社交功能障碍的一种选择。在这里，我们利用社会恐惧条件反射(SFC)的小鼠模型来研究OXT对社会恐惧的影响，并确定SFC是否导致中枢OXTR结合和局部OXT释放的变化。在社交恐惧消退训练之前，中枢注射牛磺酸，而不是精氨酸加压素，在不影响一般焦虑或运动的情况下，完全消除了Oxtr介导的社交恐惧表达。SFC导致背外侧隔(DLS)、中央杏仁核、齿状回和羊角的OXTR结合增加，并在社交恐惧消退后恢复正常，这表明这些区域构成了参与社交恐惧的发展和神经支持的大脑网络的一部分。微透析显示，在社交恐惧消退训练期间，在DLS内观察到的非条件小鼠体内OXT释放的增加在条件小鼠中得到减弱。因此，通过向DLS注入OXT来增加当地OXT的可获得性，扭转了社会恐惧。因此，大脑OXT系统的变化，包括DLS内OXTR结合和OXT释放的变化，在证监会和社交恐惧消退中发挥着重要作用。因此，我们认为，OXT系统在与社交恐惧相关的障碍中受到不利影响，如社交焦虑症，重新安装适当的OXT系统平衡可能会缓解一些症状。
Central oxytocin (OXT) has anxiolytic and pro-social properties both in humans and rodents, and has been proposed as a therapeutic option for anxiety and social dysfunctions. Here, we utilized a mouse model of social fear conditioning (SFC) to study the effects of OXT on social fear, and to determine whether SFC causes alterations in central OXT receptor (OXTR) binding and local OXT release. Central infusion of OXT, but not arginine vasopressin, prior to social fear extinction training completely abolished social fear expression in an OXTR-mediated fashion without affecting general anxiety or locomotion. SFC caused increased OXTR binding in the dorso-lateral septum (DLS), central amygdala, dentate gyrus, and cornu ammunis 1, which normalized after social fear extinction, suggesting that these areas form part of a brain network involved in the development and neural support of social fear. Microdialysis revealed that the increase in OXT release observed in unconditioned mice within the DLS during social fear extinction training was attenuated in conditioned mice. Consequently, increasing the availability of local OXT by infusion of OXT into the DLS reversed social fear. Thus, alterations in the brain OXT system, including altered OXTR binding and OXT release within the DLS, play an important role in SFC and social fear extinction. Thus, we suggest that the OXT system is adversely affected in disorders associated with social fear, such as social anxiety disorder and reinstalling an appropriate balance of the OXT system may alleviate some of the symptoms.
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影响因子：
2.9
作者：
Y. Litvin;G. Murakami;D. Pfaff
通讯作者：
Y. Litvin;G. Murakami;D. Pfaff
中央杏仁加压素和催产素对雄性大鼠条件应激反应调节的相反作用
影响因子：
5.2
作者：
B. Roozendaal;G. Schoorlemmer;A. Wiersma;S. Sluyter;P. Driscoll;J. Koolhaas;B. Bohus
通讯作者：
B. Bohus
影响因子：
4.7
作者：
David A. Slattery;I. D. Neumann
通讯作者：
David A. Slattery;I. D. Neumann
影响因子：
3.7
作者：
Jurek B;Slattery DA;Maloumby R;Hillerer K;Koszinowski S;Neumann ID;van den Burg EH
通讯作者：
van den Burg EH
DOI：
10.1098/rstb.1997.0154
发表时间：
1997-11-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Ledoux, JE;Muller, J
通讯作者：
Muller, J