The contributions of the endocannabinoid system and stress on the neural processing of reward stimuli.
The contributions of the endocannabinoid system and stress on the neural processing of reward stimuli.
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DOI：
10.1016/j.pnpbp.2020.110183
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发表时间：
2021-03-02
影响因子：
5.6
通讯作者：
Prashad S
中科院分区：
文献类型：
--
作者：
Filbey FM;Beaton D;Prashad S
大脑内源性大麻素系统通过调节食欲学习和编码物质的强化特性在奖励过程中起着至关重要的作用。证据还表明，内源性大麻素是参与对压力的情绪反应的神经元底物的重要组成部分。因此，至关重要的是要了解内源性大麻素系统和压力如何影响奖励过程，因为它们在物质使用障碍中的重要性。我们研究了调节内源性大麻素系统信号传导的因素之间的关系（即，大麻素受体基因和长期大麻暴露）和应力的fMRI BOLD反应的奖励线索，使用多元统计技术。我们发现内源性大麻素系统信号传导的代理（即，内源性大麻素基因和长期接触大麻）和压力对大麻线索的神经反应有不同的影响。具体而言，大麻素受体1（CNR1）基因的单核苷酸多态性（SNP）变体，早期生活压力和当前感知的压力调制长期重度大麻使用者的奖励反应，而脂肪酸酰胺水解酶（FAAH）基因的变体和当前感知的压力调制非使用对照组的提示引发的反应。与自然奖励线索相比，这些协会与大麻相关线索的不同神经反应有关。了解内源性大麻素系统因素和压力的贡献，导致对奖励敏感性（如大麻）的神经机制的下游影响，将有助于更好地了解内源性大麻素靶向治疗以及大麻使用障碍的个人风险。
The brain endocannabinoid system plays a crucial role in reward processes by mediating appetitive learning and encoding the reinforcing properties of substances. Evidence also suggests that endocannabinoids are an important constituent of neuronal substrates involved in emotional responses to stress. Thus, it is critical to understand how the endocannabinoid system and stress may affect reward processes given their importance in substance use disorders. We examined the relationship between factors that regulate endocannabinoid system signaling (i.e., cannabinoid receptor genes and prolonged cannabis exposure) and stress on fMRI BOLD response to reward cues using a multivariate statistical technique. We found that proxies for endocannabinoid system signaling (i.e., endocannabinoid genes and chronic exposure to cannabis) and stress have differential effects on neural response to cannabis cues. Specifically, a single nucleotide polymorphism (SNP) variant in the cannabinoid receptor 1 (CNR1) gene, early life stress, and current perceived stress modulated reward responsivity in long-term, heavy cannabis users, while a variant in the fatty acid amide hydrolase (FAAH) gene and current perceived stress modulated cue-elicited response in non-using controls. These associations were related to distinct neural responses to cannabis-related cues compared to natural reward cues. Understanding the contributions of endocannabinoid system factors and stress that lead to downstream effects on neural mechanisms underlying sensitivity to rewards, such as cannabis, will contribute towards a better understanding of endocannabinoid-targeted therapies as well as individuals risks for cannabis use disorder.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
6.9
作者：
Eckstrand KL;Hanford LC;Bertocci MA;Chase HW;Greenberg T;Lockovich J;Stiffler R;Aslam HA;Graur S;Bebko G;Forbes EE;Phillips ML
通讯作者：
Phillips ML
DOI：
10.1038/npp.2009.200
发表时间：
2010-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.9
作者：
Engelmann JB;Damaraju E;Padmala S;Pessoa L
通讯作者：
Pessoa L
影响因子：
6
作者：
Budney, AJ;Novy, PL;Hughes, JR
通讯作者：
Hughes, JR