Mechanical characterization of a bifunctional Tetronic hydrogel adhesive for soft tissues.
Mechanical characterization of a bifunctional Tetronic hydrogel adhesive for soft tissues.
复制标题
对软组织双功能四型水凝胶粘合剂的机械表征。
DOI：
10.1002/jbm.a.35310
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发表时间：
2015-03
影响因子：
4.9
通讯作者：
Nagatomi, Jiro
中科院分区：
文献类型：
--
作者：
Sanders, Lindsey;Stone, Roland;Webb, Kenneth;Mefford, Thompson;Nagatomi, Jiro
尽管目前有许多外科用的组织粘合剂和密封剂，但要在高强度、高顺应性和低肿胀之间达到有用的平衡被证明是困难的。最近的研究表明，一种四臂聚环氧丙烷-聚环氧乙烷(PPO-PEO)嵌段共聚物Tetronic可以被化学修饰以形成水凝胶组织粘合剂。在这些研究取得成功的基础上，本研究探索了特创与丙烯酸酯的双官能化用于水凝胶的化学交联，以及N-羟基琥珀酰亚胺(NHS)用于与组织胺的反应。通过搭接剪切试验测定了各种单功能和双功能Tetronic共混物(T1107ACR：T1107ACR/NHS)的粘结强度在8~74kPa之间，其中75：25(T1107ACR：T1107ACR/NHS)共混物的粘结强度最高。这些结果表明，添加NHS可以提高组织粘接强度。此外，使用大鼠膀胱的体外压力测试表明，双功能Tetronic粘结剂具有很高的柔韧性，并在数百次充填和排空循环下保持压力。总而言之，本研究的结果提供了证据，证明具有适当混合比例的双功能Tetronic粘合剂可以在体积和组织粘结强度以及膀胱等软组织的顺应性和耐久性方面实现准确的平衡。
Although a number of tissue adhesives and sealants for surgical use are currently available, attaining a useful balance in high strength, high compliance, and low swelling has proven difficult. Recent studies have demonstrated that a 4-arm poly(propylene oxide)-poly(ethylene oxide) (PPO-PEO) block copolymer, Tetronic, can be chemically modified to form a hydrogel tissue adhesive. Building on the success of these studies, the present study explored bi-functionalization of Tetronic with acrylates for chemical crosslinking of the hydrogel and N-hydroxysuccinimide (NHS) for reaction with tissue amines. The adhesive bond strengths of various uni- and bi-functional Tetronic blends (T1107 ACR: T1107 ACR/NHS) determined by lap shear testing ranged between 8 and 74 kPa, with the 75:25 (T1107 ACR: T1107 ACR/NHS) blend displaying the highest value. These results indicated that addition of NHS led to improvement of tissue bond strength over acrylation alone Furthermore, ex vivo pressure tests using the rat bladder demonstrated that the bi-functional Tetronic adhesive exhibited high compliance and maintained pressures under hundreds of filling and emptying cycles. Together, the results of the present study provided evidence that the bi-functional Tetronic adhesive with a proper blend ratio may be used to achieve an accurate balance in bulk and tissue bond strengths, as well as the compliance and durability for soft tissue such as the bladder.
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影响因子：
4.6
作者：
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通讯作者：
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作者：
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DOI：
10.1152/ajpregu.1995.269.1.r98
发表时间：
1995-07-01
影响因子：
2.8
作者：
VANASSELT, E;GROEN, J;VANMASTRIGT, R
通讯作者：
VANMASTRIGT, R