Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T.
Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T.
复制标题
DOI：
10.3389/fnins.2021.723441
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Hua J
中科院分区：
文献类型：
--
作者：
Miao X;Paez AG;Rajan S;Cao D;Liu D;Pantelyat AY;Rosenthal LI;van Zijl PCM;Bassett SS;Yousem DM;Kamath V;Hua J
嗅觉是一种基本感觉，在人类日常生活中发挥着至关重要的作用，并且可以在神经精神和神经退行性疾病中发生改变。使用基于传统回波平面成像 (EPI) 的序列的血氧水平依赖性 (BOLD) 功能磁共振成像 (fMRI) 对于嗅觉处理重要的大脑区域（例如嗅球 (OB) 和眶额皮层）可能具有挑战性，这主要是由于鼻窦腔和颞骨的大磁敏感效应导致的信号丢失和失真伪影。迄今为止，很少有研究证明功能磁共振成像在人类产科中取得成功。 T2 准备 (T2prep) BOLD fMRI 是一种替代方法，专门开发用于在受大磁敏感伪影影响的区域进行 fMRI。这项技术研究的目的是评估 T2prep BOLD fMRI 在人类嗅觉功能实验中的应用。在 7T 上对 14 名健康参与者进行了嗅觉功能磁共振成像扫描。 T2prep BOLD 在 OB、眶额皮质和颞极方面表现出比 GRE EPI BOLD 更高的敏感性。使用 T2prep BOLD 检测 OB 和相关嗅觉区域的功能激活。在嗅觉刺激过程中，所有区域都观察到了习惯效应和功能磁共振成像信号变化的双相模式。在嗅觉刺激期间观察到正激活区域和负激活区域。这些信号特征总体上与文献一致，并且与之前的人类 BOLD fMRI 研究相比，表现出良好的受试者内再现性。总之，本研究中展示的方法为未来 OB 和其他存在大量磁敏感伪影的大脑区域的嗅觉功能磁共振成像研究带来了希望。
Olfaction is a fundamental sense that plays a vital role in daily life in humans, and can be altered in neuropsychiatric and neurodegenerative diseases. Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) using conventional echo-planar-imaging (EPI) based sequences can be challenging in brain regions important for olfactory processing, such as the olfactory bulb (OB) and orbitofrontal cortex, mainly due to the signal dropout and distortion artifacts caused by large susceptibility effects from the sinonasal cavity and temporal bone. To date, few studies have demonstrated successful fMRI in the OB in humans. T2-prepared (T2prep) BOLD fMRI is an alternative approach developed especially for performing fMRI in regions affected by large susceptibility artifacts. The purpose of this technical study is to evaluate T2prep BOLD fMRI for olfactory functional experiments in humans. Olfactory fMRI scans were performed on 7T in 14 healthy participants. T2prep BOLD showed greater sensitivity than GRE EPI BOLD in the OB, orbitofrontal cortex and the temporal pole. Functional activation was detected using T2prep BOLD in the OB and associated olfactory regions. Habituation effects and a bi-phasic pattern of fMRI signal changes during olfactory stimulation were observed in all regions. Both positively and negatively activated regions were observed during olfactory stimulation. These signal characteristics are generally consistent with literature and showed a good intra-subject reproducibility comparable to previous human BOLD fMRI studies. In conclusion, the methodology demonstrated in this study holds promise for future olfactory fMRI studies in the OB and other brain regions that suffer from large susceptibility artifacts.
登录
查看更多内容
影响因子：
3.8
作者：
Doty RL;Kamath V
通讯作者：
Kamath V
DOI：
10.1007/s10334-011-0251-1
发表时间：
2011-06-01
影响因子：
2.3
作者：
Chung, Jun-Young;In, Myung-Ho;Cho, Zang-Hee
通讯作者：
Cho, Zang-Hee
影响因子：
5.7
作者：
Devlin, JT;Russell, RP;Tyler, LK
通讯作者：
Tyler, LK
影响因子：
5.3
作者：
Chaigneau, Emmanuelle;Tiret, Pascale;Charpak, Serge
通讯作者：
Charpak, Serge
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M