Delays in GABAergic interneuron development and behavioral inhibition after prenatal stress.
Delays in GABAergic interneuron development and behavioral inhibition after prenatal stress.
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DOI：
10.1002/dneu.22376
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发表时间：
2016-10
影响因子：
3
通讯作者：
Stevens HE
中科院分区：
文献类型：
--
作者：
Lussier SJ;Stevens HE
产前应激与后代的行为、认知和精神结局的改变有关。由于GABA能系统在正常发育和精神障碍中的重要性，已在动物模型中研究了产前应激对这些神经元的影响。产前应激延迟了GABA能祖细胞的迁移，但这些早期发育中断对幼年大脑中GABA能细胞继续发育的意义尚不清楚。在这里，我们通过体视学计数、基因表达以及相关的焦虑样行为和社会行为，研究了产前应激对青少年和成人内侧额叶皮质(MFC)和海马区GABA能神经元数量的影响。出生后，GABA能总种群在MFC和海马区显示出不同的轨迹。胎儿期应激改变幼鼠脑内小白蛋白神经元的比例，但小白蛋白基因的表达无明显差异。在成人大脑中，小白蛋白神经元的比例因产前应激而改变，基因表达也发生了相反的变化。成年的胎儿期应激的后代表现出对三室任务缺乏社会偏好，在高架+迷宫中焦虑样行为增加，以及在开阔场地中心的时间减少。尽管成人的GABA能细胞总数缺乏显著的组间差异，但在这些任务中的表现与MFC和海马区的GABA能细胞群有关。总之，产前应激导致GABA能细胞数量和小白蛋白亚型成熟的延迟。在发育动态期和成年期，产前应激对GABA能种群的影响可能与产前应激后出现的焦虑样行为有关。
Prenatal stress is associated with altered behavioral, cognitive, and psychiatric outcomes in offspring. Due to the importance of GABAergic systems in normal development and in psychiatric disorders, prenatal stress effects on these neurons have been investigated in animal models. Prenatal stress delays GABAergic progenitor migration, but the significance of these early developmental disruptions for the continued development of GABAergic cells in the juvenile brain is unclear. Here, we examined effects of prenatal stress on populations of GABAergic neurons in juvenile and adult medial frontal cortex (mFC) and hippocampus through stereological counting, gene expression, and relevant anxiety-like and social behaviors. Postnatally, total GABAergic populations showed altered trajectories in mFC and hippocampus. Parvalbumin neuron proportion in juvenile brain was altered by prenatal stress, but parvalbumin gene expression showed no differences. In adult brain, parvalbumin neuron proportions were altered by prenatal stress with opposite changes in gene expression. Adult prenatally-stressed offspring showed a lack of social preference on a 3-chambered task, increased anxiety-like behavior on the elevated plus maze, and reduced time in the center of an open field. Despite a lack of significant group differences in adult total GABAergic cell populations, performance on these tasks was correlated with GABAErgic populations in mFC and hippocampus. In conclusion, prenatal stress resulted in a delay in GABAergic cell number and maturation of the parvalbumin subtype. Influences of prenatal stress on GABAergic populations during developmentally dynamic periods and during adulthood may be relevant to the anxiety-like behaviors that occur after prenatal stress.
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影响因子：
2.6
作者：
Cellot G;Cherubini E
通讯作者：
Cherubini E
影响因子：
10.6
作者：
Dong E;Dzitoyeva SG;Matrisciano F;Tueting P;Grayson DR;Guidotti A
通讯作者：
Guidotti A
DOI：
10.1080/10253890802367265
发表时间：
2009-05
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Harmon KM;Greenwald ML;McFarland A;Beckwith T;Cromwell HC
通讯作者：
Cromwell HC
影响因子：
15.1
作者：
Giovanoli, Sandra;Weber, Liz;Meyer, Urs
通讯作者：
Meyer, Urs
影响因子：
16.2
作者：
Flames, N;Long, JE;Marín, O
通讯作者：
Marín, O