The effects of prenatal stress on motivation in the rat pup.
The effects of prenatal stress on motivation in the rat pup.
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DOI：
10.1080/10253890802367265
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Cromwell HC
中科院分区：
文献类型：
--
作者：
Harmon KM;Greenwald ML;McFarland A;Beckwith T;Cromwell HC
暴露于产前应激（PNS）已被证明会诱导发育中的后代的一系列心理和行为变化。我们使用啮齿动物模型来研究PNS是否会改变幼犬表达社会动机的能力。我们使用了一组行为任务，包括监测隔离后的超声波发声，条件性位置偏好，和一个新的和熟悉的气味接近测试。怀孕的Long-Evans大鼠在怀孕的第三周每天两次暴露于不可预测的可变应激源。在出生后第10天（PND）评估隔离发声。在PND 15评价幼仔对母体的亲和力。通常情况下，幼犬只有在气味与水坝相关联后，才会对气味配对环境表现出选择性偏好。这种先前的关联产生了积极的条件刺激（CS）。通常情况下，暴露在中性CS（气味与棉球配对）中的幼犬不会形成这种位置偏好。结果表明，PNS暴露的幼鼠有显着增加的痛苦发声和平等的偏好，积极和中性的条件刺激。这种类型的改变在形成早期的偏好可能是有害的，因为在社会学习的特异性和社会关系的反应能力受损下降。
Exposure to prenatal stress (PNS) has been shown to induce a set of psychological and behavioral changes in developing offspring. We used the rodent model to investigate whether PNS produces changes in the ability of the pup to express social motivation. We used a set of behavioral tasks including monitoring ultrasonic vocalizations after isolation, a conditioned place preference, and a novel and familiar odor approach test. Pregnant Long–Evans rats were exposed to an unpredictable, variable stressor twice daily during the third week of gestation. Isolation vocalizations were assessed on postnatal day (PND) 10. Pup affinity for the dam was evaluated on PND 15. Typically, pups display a selective preference for an odor-paired environment only after the odor has been associated with the dam. This previous association produces a positive conditioned stimulus (CS). Normally, pups exposed to a neutral CS (odor paired with cotton balls) do not form this place preference. Results indicate that PNS exposed pups had significantly increased distress vocalizations and an equal preference for the positive and neutral conditioned stimuli. This type of alteration in forming early preferences could be detrimental because of decreases in the specificity of social learning and an impaired responsiveness in social relationships.
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影响因子：
2.9
作者：
Cromwell, Howard C.;Johnson, Asia;Meserve, Lee A.
通讯作者：
Meserve, Lee A.
影响因子：
2.7
作者：
Estanislau, C;Morato, S
通讯作者：
Morato, S
影响因子：
2.7
作者：
Cannizzaro, C;Plescia, F;Cannizzaro, E
通讯作者：
Cannizzaro, E
影响因子：
3.6
作者：
INSEL, TR;HARBAUGH, CR
通讯作者：
HARBAUGH, CR
DOI：
10.1073/pnas.97.20.11032
发表时间：
2000-09-26
影响因子：
11.1
作者：
Lemaire, V;Koehl, M;Abrous, DN
通讯作者：
Abrous, DN