Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives.
Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives.
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超声组合纳米气泡用于癌症靶向治疗的最新进展：现状回顾和未来展望
DOI：
10.1039/d0ra08727k
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发表时间：
2021-03-29
期刊：
影响因子：
3.9
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Su C;Ren X;Nie F;Li T;Lv W;Li H;Zhang Y
抗癌药物和其他治疗分子的非特异性分布、对癌细胞的非选择性以及不利的脱靶副作用导致其较差的临床功效。因此，装载在智能纳米载体中的治疗分子的基于超声的靶向递送目前正在获得癌症治疗和管理的更广泛接受。纳米气泡（NB）是纳米尺寸的载体，其目前被用作有效的药物/基因递送系统，因为它们可以将药物/基因选择性地递送到靶位点。因此，结合超声与NB的应用，最近已经证明了具有触发释放行为的肿瘤组织中抗癌分子的定位增加。因此，在靶肿瘤组织中实现了药物/基因的有效治疗浓度，最终提高了治疗功效，并且对其他非癌组织的副作用最小。本文综述了超声-纳米气泡联合靶向治疗癌症的策略。本综述的第一部分讨论了NB的组成和配方参数。接下来，我们说明了结合NB和超声的相互作用和生物效应。随后，我们解释了NB与US结合用于靶向癌症治疗的潜力。最后，提出了当前和未来的改进方向。NBs与超声相结合证明了增强抗癌药物靶向性和提高疗效的能力。
The non-specific distribution, non-selectivity towards cancerous cells, and adverse off-target side effects of anticancer drugs and other therapeutic molecules lead to their inferior clinical efficacy. Accordingly, ultrasound-based targeted delivery of therapeutic molecules loaded in smart nanocarriers is currently gaining wider acceptance for the treatment and management of cancer. Nanobubbles (NBs) are nanosize carriers, which are currently used as effective drug/gene delivery systems because they can deliver drugs/genes selectively to target sites. Thus, combining the applications of ultrasound with NBs has recently demonstrated increased localization of anticancer molecules in tumor tissues with triggered release behavior. Consequently, an effective therapeutic concentration of drugs/genes is achieved in target tumor tissues with ultimately increased therapeutic efficacy and minimal side-effects on other non-cancerous tissues. This review illustrates present developments in the field of ultrasound-nanobubble combined strategies for targeted cancer treatment. The first part of this review discusses the composition and the formulation parameters of NBs. Next, we illustrate the interactions and biological effects of combining NBs and ultrasound. Subsequently, we explain the potential of NBs combined with US for targeted cancer therapeutics. Finally, the present and future directions for the improvement of current methods are proposed. NBs combined with ultrasound demonstrated the ability to enhance the targeting of anticancer agents and improve the efficacy.
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