Small interfering RNA for cancer treatment: overcoming hurdles in delivery.
Small interfering RNA for cancer treatment: overcoming hurdles in delivery.
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DOI：
10.1016/j.apsb.2020.10.005
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Zacconi FC
中科院分区：
文献类型：
--
作者：
Charbe NB;Amnerkar ND;Ramesh B;Tambuwala MM;Bakshi HA;Aljabali AAA;Khadse SC;Satheeshkumar R;Satija S;Metha M;Chellappan DK;Shrivastava G;Gupta G;Negi P;Dua K;Zacconi FC
在许多方面，癌细胞与健康细胞不同。许多战术纳米药物输送系统都是基于癌症和健康细胞之间的差异。目前，基于纳米技术的递送系统是将基于 DNA 的产品递送至癌细胞的最有前途的工具。本综述旨在重点介绍用于将 siRNA 递送至癌细胞的脂质和聚合物纳米载体的最新进展。它还提供了有关 siRNA 开发及其作用机制的必要信息。总的来说，这篇综述让我们对基于脂质和聚合物的药物输送系统有了清晰的认识，这些系统将来可能成为将基本 siRNA 生物学转化为基于 siRNA 的癌症疗法的基础。重点介绍了用于将 siRNA 递送至癌细胞的脂质和聚合物纳米载体的最新进展。它还提供了有关 siRNA 开发及其作用机制的必要信息。
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies. The latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells were highlighted. It also provides the necessary information about siRNA development and its mechanism of action.
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影响因子：
4
作者：
BENNETT, MJ;NANTZ, MH;MALONE, RW
通讯作者：
MALONE, RW
DOI：
10.3181/0808-mr-250
发表时间：
2009-02
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Blanco E;Kessinger CW;Sumer BD;Gao J
通讯作者：
Gao J
影响因子：
2.8
作者：
Arami, S.;Rashidi, M. R.;Entezami, A. A.
通讯作者：
Entezami, A. A.
影响因子：
64.8
作者：
Brummelkamp, TR;Nijman, SMB;Bernards, R
通讯作者：
Bernards, R
影响因子：
14
作者：
Andersen, Morten O.;Lichawska, Agata;Howard, Kenneth A.
通讯作者：
Howard, Kenneth A.