Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics.

Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics.
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DOI:
10.3389/fncel.2021.761416
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发表时间:
2021
影响因子:
5.3
通讯作者:
Kefalov VJ
Kefalov VJ
中科院分区:
医学2区
文献类型:
--
作者:
Genovese F;Reisert J;Kefalov VJ

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在过去的几十年里,我们对光感受器和嗅觉感觉神经元功能的理解取得了巨大进展,揭示了决定其特性以及最终决定我们视觉和嗅觉能力的机制。这一进展在很大程度上是由生理实验工具和基因操作的强大结合推动的,这使我们能够识别这些感觉神经元转导级联中的主要分子参与者,它们的特性如何影响刺激的检测和辨别,以及疾病如何影响我们的视觉和嗅觉。这篇综述总结了光感受器和嗅觉感觉神经元的一些共同和独特的特征,这些特征使这些细胞的研究如此令人兴奋。
The past decades have seen tremendous progress in our understanding of the function of photoreceptors and olfactory sensory neurons, uncovering the mechanisms that determine their properties and, ultimately, our ability to see and smell. This progress has been driven to a large degree by the powerful combination of physiological experimental tools and genetic manipulations, which has enabled us to identify the main molecular players in the transduction cascades of these sensory neurons, how their properties affect the detection and discrimination of stimuli, and how diseases affect our senses of vision and smell. This review summarizes some of the common and unique features of photoreceptors and olfactory sensory neurons that make these cells so exciting to study.
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